DegronMD

Uniprot ID: Q5H9K5

Source protein: Zinc finger matrin-type protein 1

Source gene: ZMAT1

Class: DEG_SCF_TRCP1_1

Location: 344:349

E3 ligase: BTRC

DEGRON score: 0.9991

ASA_SCORE: 73.9667

COIL: 0.7445

CONS_SCORE: 0.3977

DSS_SCORE: 0.5196

HELIX: 0.0977

FCONS_SCORE: 1.1311

RIG_SCORE: 0.6623

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S345F	ACH-002396	Bone Cancer	CCLE	DSGPRS	DEG_SCF_TRCP1_1	0.7982
p.S345F	Sarc9371	bone	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	0.7982
p.G346R	TCGA-YD-A89C	SKCM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	0.7568
p.G346R	DO219501	SKCM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.7568
p.P347T	TCGA-09-2044	OV	TCGA	DSGPRS	DEG_SCF_TRCP1_1	0.5919
p.P347T	DO28923	OV	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.5919
p.M351I	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	0.2778
p.M351I	ACH-000824	Esophageal Cancer	CCLE	DSGPRS	DEG_SCF_TRCP1_1	0.2778
p.M351I	KYSE-510	oesophagus	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	0.2778
p.E353G	TCGA-A6-5665	COAD	TCGA	DSGPRS	DEG_SCF_TRCP1_1	0.2222
p.E353G	DO9756	COAD	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.2222
p.H337N	SIDM00231	Kidney Carcinoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	0.1389
p.H337N	SIDM00445	Esophageal Carcinoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	0.1389
p.H337N	ACH-002292	Esophageal Cancer	CCLE	DSGPRS	DEG_SCF_TRCP1_1	0.1389
p.H337N	OACp4C	oesophagus	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	0.1389
p.H337N	NCC010	kidney	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	0.1389
p.S357L	SIDM00336	Melanoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	0.1111
p.S357L	ACH-000881	Skin Cancer	CCLE	DSGPRS	DEG_SCF_TRCP1_1	0.1111
p.S357L	MEL-JUSO	skin	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	0.1111
p.H358Y	TCGA-AA-3672	COAD	TCGA	DSGPRS	DEG_SCF_TRCP1_1	0.0833
p.H358Y	DO9010	COAD	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.0833
p.D335Y	SIDM00994	T-Lymphoblastic Leukemia	GDSC	DSGPRS	DEG_SCF_TRCP1_1	0.0833
p.D335Y	ACH-000105	Leukemia	CCLE	DSGPRS	DEG_SCF_TRCP1_1	0.0833
p.D335Y	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMP0	Thrombospondin type-1 domain-containing protein 4	DEG_SCF_TRCP1_1	228:233	DSGPRS	BTRC	0.9377	More...
Q5H9K5	Zinc finger matrin-type protein 1	DEG_SCF_TRCP1_1	344:349	DSGPRS	BTRC	0.9991	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons