DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGPRS
Uniprot ID:
Q5H9K5
Source protein:
Zinc finger matrin-type protein 1
Source gene:
ZMAT1
Class:
DEG_SCF_TRCP1_1
Location:
344:349
E3 ligase:
BTRC
DEGRON score:
0.9991
ASA_SCORE:
73.9667
COIL:
0.7445
CONS_SCORE:
0.3977
DSS_SCORE:
0.5196
HELIX:
0.0977
FCONS_SCORE:
1.1311
RIG_SCORE:
0.6623
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P347T
TCGA-09-2044
OV
TCGA
DSGPRS
DEG_SCF_TRCP1_1
0.5919
p.P347T
DO28923
OV
ICGC
DSGPRS
DEG_SCF_TRCP1_1
0.5919
p.E353G
TCGA-A6-5665
COAD
TCGA
DSGPRS
DEG_SCF_TRCP1_1
0.2222
p.E353G
DO9756
COAD
ICGC
DSGPRS
DEG_SCF_TRCP1_1
0.2222
p.H358Y
TCGA-AA-3672
COAD
TCGA
DSGPRS
DEG_SCF_TRCP1_1
0.0833
p.H358Y
DO9010
COAD
ICGC
DSGPRS
DEG_SCF_TRCP1_1
0.0833
p.G346R
TCGA-YD-A89C
SKCM
TCGA
DSGPRS
DEG_SCF_TRCP1_1
0.7568
p.G346R
DO219501
SKCM
ICGC
DSGPRS
DEG_SCF_TRCP1_1
0.7568
p.D335Y
SIDM00994
T-Lymphoblastic Leukemia
GDSC
DSGPRS
DEG_SCF_TRCP1_1
0.0833
p.D335Y
ACH-000105
Leukemia
CCLE
DSGPRS
DEG_SCF_TRCP1_1
0.0833
p.D335Y
ALL-SIL
haematopoietic_and_lymphoid_tissue
COSMIC
DSGPRS
DEG_SCF_TRCP1_1
0.0833
p.S357L
SIDM00336
Melanoma
GDSC
DSGPRS
DEG_SCF_TRCP1_1
0.1111
p.S357L
ACH-000881
Skin Cancer
CCLE
DSGPRS
DEG_SCF_TRCP1_1
0.1111
p.S357L
MEL-JUSO
skin
COSMIC
DSGPRS
DEG_SCF_TRCP1_1
0.1111
p.H337N
SIDM00231
Kidney Carcinoma
GDSC
DSGPRS
DEG_SCF_TRCP1_1
0.1389
p.H337N
SIDM00445
Esophageal Carcinoma
GDSC
DSGPRS
DEG_SCF_TRCP1_1
0.1389
p.H337N
ACH-002292
Esophageal Cancer
CCLE
DSGPRS
DEG_SCF_TRCP1_1
0.1389
p.H337N
OACp4C
oesophagus
COSMIC
DSGPRS
DEG_SCF_TRCP1_1
0.1389
p.H337N
NCC010
kidney
COSMIC
DSGPRS
DEG_SCF_TRCP1_1
0.1389
p.M351I
SIDM01026
Esophageal Squamous Cell Carcinoma
GDSC
DSGPRS
DEG_SCF_TRCP1_1
0.2778
p.M351I
ACH-000824
Esophageal Cancer
CCLE
DSGPRS
DEG_SCF_TRCP1_1
0.2778
p.M351I
KYSE-510
oesophagus
COSMIC
DSGPRS
DEG_SCF_TRCP1_1
0.2778
p.S345F
ACH-002396
Bone Cancer
CCLE
DSGPRS
DEG_SCF_TRCP1_1
0.7982
p.S345F
Sarc9371
bone
COSMIC
DSGPRS
DEG_SCF_TRCP1_1
0.7982
Drug responses associated with ZMAT1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGPRS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6ZMP0
Thrombospondin type-1 domain-containing protein 4
DEG_SCF_TRCP1_1
228:233
DSGPRS
BTRC
0.9377
More...
Q5H9K5
Zinc finger matrin-type protein 1
DEG_SCF_TRCP1_1
344:349
DSGPRS
BTRC
0.9991
More...