DegronMD

Uniprot ID: Q6ZMP0

Source protein: Thrombospondin type-1 domain-containing protein 4

Source gene: THSD4

Class: DEG_SCF_TRCP1_1

Location: 228:233

E3 ligase: BTRC

DEGRON score: 0.9377

ASA_SCORE: 78.3167

COIL: 0.8467

CONS_SCORE: 0.42

DSS_SCORE: 0.662

HELIX: 0.1023

FCONS_SCORE: 0.9662

RIG_SCORE: 0.588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G222E	TCGA-06-2565	GBM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	0.1667
p.G222E	DO12730	GBM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.1667
p.A238V	TCGA-06-A6S1	GBM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	0.1944
p.A238V	DO50113	GBM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.1944
p.A238V	SIDM00442	Thyroid Gland Carcinoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	0.1944
p.A238V	ML-1	thyroid	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	0.1944
p.R232C	TCGA-D9-A6EC	SKCM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	0.719
p.R232C	TCGA-FW-A3R5	SKCM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	0.719
p.R232C	DO48314	ESCA	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.719
p.R232C	DO220875	MELA	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.719
p.R232C	DO37406	SKCM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.719
p.R232C	DO50291	SKCM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.719
p.D228N	TCGA-FI-A2D0	UCEC	TCGA	DSGPRS	DEG_SCF_TRCP1_1	0.6932
p.D228N	TCGA-GF-A6C9	SKCM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	0.6932
p.D228N	DO51254	SKCM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.6932
p.D228N	DO43891	UCEC	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.6932
p.P219S	TCGA-FR-A69P	SKCM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	0.0833
p.P219S	DO47292	SKCM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.0833
p.A240P	DO233754	GACA	ICGC	DSGPRS	DEG_SCF_TRCP1_1	0.1389
p.R232H	SIDM00555	Glioblastoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	0.7133
p.R232H	ACH-000631	Brain Cancer	CCLE	DSGPRS	DEG_SCF_TRCP1_1	0.7133
p.R232H	KS-1	central_nervous_system	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMP0	Thrombospondin type-1 domain-containing protein 4	DEG_SCF_TRCP1_1	228:233	DSGPRS	BTRC	0.9377	More...
Q5H9K5	Zinc finger matrin-type protein 1	DEG_SCF_TRCP1_1	344:349	DSGPRS	BTRC	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons