DegronMD - Q6ZMP0(THSD4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G222E	TCGA-06-2565	GBM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation rewiring degron network	0.1667
p.G222E	DO12730	GBM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation rewiring degron network	0.1667
p.A238V	TCGA-06-A6S1	GBM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation rewiring degron network	0.1944
p.A238V	DO50113	GBM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation rewiring degron network	0.1944
p.A238V	SIDM00442	Thyroid Gland Carcinoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation rewiring degron network	0.1944
p.A238V	ML-1	thyroid	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation rewiring degron network	0.1944
p.R232C	TCGA-D9-A6EC	SKCM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.719
p.R232C	TCGA-FW-A3R5	SKCM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.719
p.R232C	DO48314	ESCA	ICGC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.719
p.R232C	DO220875	MELA	ICGC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.719
p.R232C	DO37406	SKCM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.719
p.R232C	DO50291	SKCM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.719
p.D228N	TCGA-FI-A2D0	UCEC	TCGA	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.6932
p.D228N	TCGA-GF-A6C9	SKCM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.6932
p.D228N	DO51254	SKCM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.6932
p.D228N	DO43891	UCEC	ICGC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.6932
p.P219S	TCGA-FR-A69P	SKCM	TCGA	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation rewiring degron network	0.0833
p.P219S	DO47292	SKCM	ICGC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation rewiring degron network	0.0833
p.A240P	DO233754	GACA	ICGC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation rewiring degron network	0.1389
p.R232H	SIDM00555	Glioblastoma	GDSC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.7133
p.R232H	ACH-000631	Brain Cancer	CCLE	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.7133
p.R232H	KS-1	central nervous system	COSMIC	DSGPRS	DEG_SCF_TRCP1_1	228:233	Mutation altering degron motif	0.7133

Kaplan plot for THSD4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THSD4

UniProt ID: Q6ZMP0

Entrez ID: 79875

Protein name: Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THSD4 in