DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
PWWP3B
UniProt ID:
Q5H9M0
Entrez ID:
139221
Protein name:
PWWP domain-containing DNA repair factor 3B (PWWP3B) (Mutated melanoma-associated antigen 1-like protein 1) (MUM1-like protein 1) (PWWP domain-containing protein MUM1L1)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
extracellular exosome [GO:0070062]...
extracellular exosome [GO:0070062]
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Open in full screen with detailed sequence annotations
PWWP3B
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.D375H
SIDM00564
Ovarian Carcinoma
GDSC
SRINLSLLD
DEG_APCC_DBOX_1
362:370
Mutation rewiring degron network
0.1944
p.D375H
OVISE
ovary
COSMIC
SRINLSLLD
DEG_APCC_DBOX_1
362:370
Mutation rewiring degron network
0.1944
p.R363H
SIDM00217
Colorectal Carcinoma
GDSC
SRINLSLLD
DEG_APCC_DBOX_1
362:370
Mutation altering degron motif
0.8244
p.R363H
SNU-1040
large intestine
COSMIC
SRINLSLLD
DEG_APCC_DBOX_1
362:370
Mutation altering degron motif
0.8244
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for PWWP3B in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc