DegronMD

Uniprot ID: Q5H9M0

Source protein: PWWP domain-containing DNA repair factor 3B

Source gene: PWWP3B

Class: DEG_APCC_DBOX_1

Location: 362:370

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9724

ASA_SCORE: 100.5667

COIL: 0.8179

CONS_SCORE: 0.4776

DSS_SCORE: 0.4337

HELIX: 0.164

FCONS_SCORE: 0.7317

RIG_SCORE: 0.7394

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D375H	SIDM00564	Ovarian Carcinoma	GDSC	SRINLSLLD	DEG_APCC_DBOX_1	0.1944
p.D375H	OVISE	ovary	COSMIC	SRINLSLLD	DEG_APCC_DBOX_1	0.1944
p.R363H	SIDM00217	Colorectal Carcinoma	GDSC	SRINLSLLD	DEG_APCC_DBOX_1	0.8244
p.R363H	SNU-1040	large_intestine	COSMIC	SRINLSLLD	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5H9M0	PWWP domain-containing DNA repair factor 3B	DEG_APCC_DBOX_1	362:370	SRINLSLLD	APC,CDC20,FZR1	0.9724	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons