DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
CT47A1; CT47A2; CT47A3; C
UniProt ID:
Q5JQC4
Entrez ID:
100507170
Protein name:
Cancer/testis antigen 47A (Cancer/testis antigen 47) (CT47)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
CT47A1; CT47A2; CT47A3; C
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.S38P
DO48438
BLCA
ICGC
DSGPDSS
DEG_SCF_TRCP1_1
37:43
Mutation altering degron motif
0.6752
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for CT47A1; CT47A2; CT47A3; C in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc