DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S38P	DO48438	BLCA	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.6752

Drug responses associated with CT47A1; CT47A2; CT47A3; CT47A4; CT47A5; CT47A6; CT47A7; CT47A8; CT47A9; CT47A10; CT47A11; CT47A12 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50

All proteins holding degron of DSGPDSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JQC4	Cancer/testis antigen 47A	DEG_SCF_TRCP1_1	37:43	DSGPDSS	BTRC	0.9541	More...
P0C2W7	Cancer/testis antigen 47B	DEG_SCF_TRCP1_1	37:43	DSGPDSS	BTRC	0.8841	More...