DegronMD

Uniprot ID: P0C2W7

Source protein: Cancer/testis antigen 47B

Source gene: CT47B1

Class: DEG_SCF_TRCP1_1

Location: 37:43

E3 ligase: BTRC

DEGRON score: 0.8841

ASA_SCORE: 64.4429

COIL: 0.8643

CONS_SCORE: 0.9178

DSS_SCORE: 0.817

HELIX: 0.0716

FCONS_SCORE: 1.0253

RIG_SCORE: 0.5409

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G36S	TCGA-2W-A8YY	CESC	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	0.3056
p.G36S	TCGA-CN-5369	HNSC	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	0.3056
p.G36S	DO223732	CESC	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.3056
p.G36S	DO16069	HNSC	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.3056
p.S38C	TCGA-75-6206	LUAD	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	0.7541
p.S38C	DO23614	LUAD	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.7541
p.P40S	TCGA-77-7463	LUSC	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	0.5641
p.P40S	DO26716	LUSC	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.5641
p.A48V	TCGA-AJ-A3BH	UCEC	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	0.1944
p.A48V	DO41638	UCEC	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.1944
p.P47S	TCGA-BR-7851	STAD	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	0.2222
p.P47S	DO38711	STAD	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.2222
p.G53E	TCGA-EE-A29D	SKCM	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	0.0556
p.G53E	DO38123	SKCM	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.0556
p.G39D	TCGA-EE-A2MR	SKCM	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	0.7198
p.G39D	DO37819	SKCM	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.7198
p.G53V	TCGA-ER-A19G	SKCM	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	0.0556
p.G53V	DO47284	SKCM	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.0556
p.G29R	TCGA-MU-A8JM	CESC	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	0.1111
p.G29R	DO49002	CESC	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.1111
p.E34K	TCGA-ZF-A9R5	BLCA	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	0.25
p.E34K	DO219063	BLCA	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.25
p.M45V	DO229010	COCA	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	DO228947	LICA	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	SIDM00367	Small Cell Lung Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	SIDM01005	Acute Myeloid Leukemia	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	SIDM00296	Small Cell Lung Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	SIDM00207	Glioblastoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	SIDM01660	Kidney Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	SIDM00008	Ovarian Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	SIDM01782	Oral Cavity Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	SIDM01559	Melanoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	SIDM01753	Gastric Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	LU-134-A	lung	COSMIC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	H-EMC-SS	bone	COSMIC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	SBC-3	lung	COSMIC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.M45V	KASUMI-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPDSS	DEG_SCF_TRCP1_1	0.2778
p.P47L	DO50970	LICA	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.2222
p.E50K	DO220859	MELA	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	0.1389
p.D41N	SIDM01278	Colorectal Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	0.5821
p.G53R	SIDM02015	Colorectal Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	0.0556
p.A27V	ACH-000612	Lymphoma	CCLE	DSGPDSS	DEG_SCF_TRCP1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGPDSS

Degron related mutations and impact score

Drug responses associated with CT47B1 mutations

All proteins holding degron of DSGPDSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JQC4	Cancer/testis antigen 47A	DEG_SCF_TRCP1_1	37:43	DSGPDSS	BTRC	0.9541	More...
P0C2W7	Cancer/testis antigen 47B	DEG_SCF_TRCP1_1	37:43	DSGPDSS	BTRC	0.8841	More...