DegronMD - P0C2W7(CT47B1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E185K	TCGA-28-1749	GBM	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.0556
p.E185K	TCGA-Z2-A8RT	SKCM	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.0556
p.E185K	DO11423	GBM	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.0556
p.E185K	DO51301	SKCM	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.0556
p.G36S	TCGA-2W-A8YY	CESC	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.3056
p.G36S	TCGA-CN-5369	HNSC	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.3056
p.G36S	DO223732	CESC	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.3056
p.G36S	DO16069	HNSC	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.3056
p.A199V	TCGA-55-A492	LUAD	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.5825
p.A199V	TCGA-AA-3984	COAD	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.5825
p.A199V	DO9002	COAD	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.5825
p.A199V	DO23708	LUAD	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.5825
p.E198D	TCGA-66-2787	LUSC	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.5647
p.E198D	DO26647	LUSC	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.5647
p.S38C	TCGA-75-6206	LUAD	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation altering degron motif	0.7541
p.S38C	DO23614	LUAD	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation altering degron motif	0.7541
p.P40S	TCGA-77-7463	LUSC	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation altering degron motif	0.5641
p.P40S	DO26716	LUSC	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation altering degron motif	0.5641
p.D210E	TCGA-77-8156	LUSC	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1944
p.D210E	DO228931	LICA	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1944
p.D210E	DO26802	LUSC	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1944
p.A193S	TCGA-97-7546	LUAD	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.2778
p.A193S	DO23762	LUAD	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.2778
p.S195L	TCGA-A5-A0GP	UCEC	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.7667
p.S195L	TCGA-AA-3696	COAD	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.7667
p.S195L	DO10004	COAD	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.7667
p.S195L	DO52388	LUSC	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.7667
p.S195L	DO41109	UCEC	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.7667
p.E213K	TCGA-AC-A23H	BRCA	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1111
p.E213K	DO2401	BRCA	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1111
p.E213K	SIDM01612	Endometrial Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1111
p.A48V	TCGA-AJ-A3BH	UCEC	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.1944
p.A48V	DO41638	UCEC	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.1944
p.V196I	TCGA-AP-A051	UCEC	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.5965
p.V196I	DO42673	UCEC	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.5965
p.G188S	TCGA-B5-A0JU	UCEC	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.G188S	TCGA-R5-A7ZR	STAD	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.G188S	DO222343	STAD	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.G188S	DO40819	UCEC	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.G188S	SIDM00999	Bladder Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.G188S	ACH-000973	Bladder Cancer	CCLE	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.G188S	639-V	urinary tract	COSMIC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.A206V	TCGA-B5-A11U	UCEC	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.3056
p.A206V	DO40804	UCEC	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.3056
p.P47S	TCGA-BR-7851	STAD	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2222
p.P47S	DO38711	STAD	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2222
p.G53E	TCGA-EE-A29D	SKCM	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.0556
p.G53E	DO38123	SKCM	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.0556
p.A215T	TCGA-EE-A29E	SKCM	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.0556
p.A215T	DO37831	SKCM	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.0556
p.G188D	TCGA-EE-A29N	SKCM	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.G188D	DO38001	SKCM	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.G39D	TCGA-EE-A2MR	SKCM	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation altering degron motif	0.7198
p.G39D	DO37819	SKCM	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation altering degron motif	0.7198
p.G53V	TCGA-ER-A19G	SKCM	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.0556
p.G53V	DO47284	SKCM	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.0556
p.A215D	TCGA-L5-A4ON	ESCA	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.0556
p.A200S	TCGA-L9-A7SV	LUAD	TCGA	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.6477
p.A200S	DO49875	LUAD	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.6477
p.G29R	TCGA-MU-A8JM	CESC	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.1111
p.G29R	DO49002	CESC	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.1111
p.E34K	TCGA-ZF-A9R5	BLCA	TCGA	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.25
p.E34K	DO219063	BLCA	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.25
p.A200P	DO6356	CLLE	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.6392
p.M45V	DO229010	COCA	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	DO228947	LICA	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	SIDM00367	Small Cell Lung Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	SIDM01005	Acute Myeloid Leukemia	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	SIDM00296	Small Cell Lung Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	SIDM00207	Glioblastoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	SIDM01660	Kidney Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	SIDM00008	Ovarian Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	SIDM01782	Oral Cavity Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	SIDM01559	Melanoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	SIDM01753	Gastric Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	LU-134-A	lung	COSMIC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	H-EMC-SS	bone	COSMIC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	SBC-3	lung	COSMIC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.M45V	KASUMI-1	haematopoietic and lymphoid tissue	COSMIC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2778
p.P47L	DO50970	LICA	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.2222
p.P203S	DO231072	LUSC	ICGC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.6752
p.E50K	DO220859	MELA	ICGC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.1389
p.D41N	SIDM01278	Colorectal Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation altering degron motif	0.5821
p.G53R	SIDM02015	Colorectal Carcinoma	GDSC	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.0556
p.A199S	SIDM00474	Ovarian Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.6477
p.A199S	ACH-000688	Ovarian Cancer	CCLE	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.6477
p.A199S	OV-7	ovary	COSMIC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.6477
p.G188R	SIDM00493	Other Solid Cancers	GDSC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.G188R	NCI-H292	lung	COSMIC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.A215V	SIDM00537	Colorectal Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.0556
p.A215V	ACH-001345	Colon/Colorectal Cancer	CCLE	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.0556
p.A215V	GP5d	large intestine	COSMIC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.0556
p.E198G	SIDM00068	Colorectal Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.7199
p.E198G	SIDM00954	Breast Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.7199
p.E198G	SIDM01664	Prostate Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation altering degron motif	0.7199
p.A194V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.3056
p.A194V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.3056
p.A212G	SIDM00867	Glioblastoma	GDSC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.A212G	DBTRG-05MG	central nervous system	COSMIC	SVQEAASVPEP	DEG_COP1_1	195:205	Mutation rewiring degron network	0.1389
p.A27V	ACH-000612	Lymphoma	CCLE	DSGPDSS	DEG_SCF_TRCP1_1	37:43	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CT47B1

UniProt ID: P0C2W7

Entrez ID: 643311

Protein name: Cancer/testis antigen 47B (Cancer/testis antigen 47.13) (CT47.13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CT47B1 in