DegronMD

Uniprot ID: P0C2W7

Source protein: Cancer/testis antigen 47B

Source gene: CT47B1

Class: DEG_COP1_1

Location: 195:205

E3 ligase: COP1

DEGRON score: 0.8447

ASA_SCORE: 85.5909

COIL: 0.6745

CONS_SCORE: 0.865

DSS_SCORE: 0.5179

HELIX: 0.2997

FCONS_SCORE: 1.1346

RIG_SCORE: 0.6757

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E185K	TCGA-28-1749	GBM	TCGA	SVQEAASVPEP	DEG_COP1_1	0.0556
p.E185K	TCGA-Z2-A8RT	SKCM	TCGA	SVQEAASVPEP	DEG_COP1_1	0.0556
p.E185K	DO11423	GBM	ICGC	SVQEAASVPEP	DEG_COP1_1	0.0556
p.E185K	DO51301	SKCM	ICGC	SVQEAASVPEP	DEG_COP1_1	0.0556
p.A199V	TCGA-55-A492	LUAD	TCGA	SVQEAASVPEP	DEG_COP1_1	0.5825
p.A199V	TCGA-AA-3984	COAD	TCGA	SVQEAASVPEP	DEG_COP1_1	0.5825
p.A199V	DO9002	COAD	ICGC	SVQEAASVPEP	DEG_COP1_1	0.5825
p.A199V	DO23708	LUAD	ICGC	SVQEAASVPEP	DEG_COP1_1	0.5825
p.E198D	TCGA-66-2787	LUSC	TCGA	SVQEAASVPEP	DEG_COP1_1	0.5647
p.E198D	DO26647	LUSC	ICGC	SVQEAASVPEP	DEG_COP1_1	0.5647
p.D210E	TCGA-77-8156	LUSC	TCGA	SVQEAASVPEP	DEG_COP1_1	0.1944
p.D210E	DO228931	LICA	ICGC	SVQEAASVPEP	DEG_COP1_1	0.1944
p.D210E	DO26802	LUSC	ICGC	SVQEAASVPEP	DEG_COP1_1	0.1944
p.A193S	TCGA-97-7546	LUAD	TCGA	SVQEAASVPEP	DEG_COP1_1	0.2778
p.A193S	DO23762	LUAD	ICGC	SVQEAASVPEP	DEG_COP1_1	0.2778
p.S195L	TCGA-A5-A0GP	UCEC	TCGA	SVQEAASVPEP	DEG_COP1_1	0.7667
p.S195L	TCGA-AA-3696	COAD	TCGA	SVQEAASVPEP	DEG_COP1_1	0.7667
p.S195L	DO10004	COAD	ICGC	SVQEAASVPEP	DEG_COP1_1	0.7667
p.S195L	DO52388	LUSC	ICGC	SVQEAASVPEP	DEG_COP1_1	0.7667
p.S195L	DO41109	UCEC	ICGC	SVQEAASVPEP	DEG_COP1_1	0.7667
p.E213K	TCGA-AC-A23H	BRCA	TCGA	SVQEAASVPEP	DEG_COP1_1	0.1111
p.E213K	DO2401	BRCA	ICGC	SVQEAASVPEP	DEG_COP1_1	0.1111
p.E213K	SIDM01612	Endometrial Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	0.1111
p.V196I	TCGA-AP-A051	UCEC	TCGA	SVQEAASVPEP	DEG_COP1_1	0.5965
p.V196I	DO42673	UCEC	ICGC	SVQEAASVPEP	DEG_COP1_1	0.5965
p.G188S	TCGA-B5-A0JU	UCEC	TCGA	SVQEAASVPEP	DEG_COP1_1	0.1389
p.G188S	TCGA-R5-A7ZR	STAD	TCGA	SVQEAASVPEP	DEG_COP1_1	0.1389
p.G188S	DO222343	STAD	ICGC	SVQEAASVPEP	DEG_COP1_1	0.1389
p.G188S	DO40819	UCEC	ICGC	SVQEAASVPEP	DEG_COP1_1	0.1389
p.G188S	SIDM00999	Bladder Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	0.1389
p.G188S	ACH-000973	Bladder Cancer	CCLE	SVQEAASVPEP	DEG_COP1_1	0.1389
p.G188S	639-V	urinary_tract	COSMIC	SVQEAASVPEP	DEG_COP1_1	0.1389
p.A206V	TCGA-B5-A11U	UCEC	TCGA	SVQEAASVPEP	DEG_COP1_1	0.3056
p.A206V	DO40804	UCEC	ICGC	SVQEAASVPEP	DEG_COP1_1	0.3056
p.A215T	TCGA-EE-A29E	SKCM	TCGA	SVQEAASVPEP	DEG_COP1_1	0.0556
p.A215T	DO37831	SKCM	ICGC	SVQEAASVPEP	DEG_COP1_1	0.0556
p.G188D	TCGA-EE-A29N	SKCM	TCGA	SVQEAASVPEP	DEG_COP1_1	0.1389
p.G188D	DO38001	SKCM	ICGC	SVQEAASVPEP	DEG_COP1_1	0.1389
p.A215D	TCGA-L5-A4ON	ESCA	TCGA	SVQEAASVPEP	DEG_COP1_1	0.0556
p.A200S	TCGA-L9-A7SV	LUAD	TCGA	SVQEAASVPEP	DEG_COP1_1	0.6477
p.A200S	DO49875	LUAD	ICGC	SVQEAASVPEP	DEG_COP1_1	0.6477
p.A200P	DO6356	CLLE	ICGC	SVQEAASVPEP	DEG_COP1_1	0.6392
p.P203S	DO231072	LUSC	ICGC	SVQEAASVPEP	DEG_COP1_1	0.6752
p.A199S	SIDM00474	Ovarian Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	0.6477
p.A199S	ACH-000688	Ovarian Cancer	CCLE	SVQEAASVPEP	DEG_COP1_1	0.6477
p.A199S	OV-7	ovary	COSMIC	SVQEAASVPEP	DEG_COP1_1	0.6477
p.G188R	SIDM00493	Other Solid Cancers	GDSC	SVQEAASVPEP	DEG_COP1_1	0.1389
p.G188R	NCI-H292	lung	COSMIC	SVQEAASVPEP	DEG_COP1_1	0.1389
p.A215V	SIDM00537	Colorectal Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	0.0556
p.A215V	ACH-001345	Colon/Colorectal Cancer	CCLE	SVQEAASVPEP	DEG_COP1_1	0.0556
p.A215V	GP5d	large_intestine	COSMIC	SVQEAASVPEP	DEG_COP1_1	0.0556
p.E198G	SIDM00068	Colorectal Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	0.7199
p.E198G	SIDM00954	Breast Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	0.7199
p.E198G	SIDM01664	Prostate Carcinoma	GDSC	SVQEAASVPEP	DEG_COP1_1	0.7199
p.A194V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	SVQEAASVPEP	DEG_COP1_1	0.3056
p.A194V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	SVQEAASVPEP	DEG_COP1_1	0.3056
p.A212G	SIDM00867	Glioblastoma	GDSC	SVQEAASVPEP	DEG_COP1_1	0.1389
p.A212G	DBTRG-05MG	central_nervous_system	COSMIC	SVQEAASVPEP	DEG_COP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SVQEAASVPEP

Degron related mutations and impact score

Drug responses associated with CT47B1 mutations

All proteins holding degron of SVQEAASVPEP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C2W7	Cancer/testis antigen 47B	DEG_COP1_1	195:205	SVQEAASVPEP	COP1	0.8447	More...