DegronMD - Q5JTZ9(AARS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D512N	TCGA-18-3409	LUSC	TCGA	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.5821
p.D512N	DO26444	LUSC	ICGC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.5821
p.S513N	TCGA-85-A4CN	LUSC	TCGA	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.5958
p.S513N	DO45510	LUSC	ICGC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.5958
p.R504C	TCGA-AA-A02R	COAD	TCGA	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.1111
p.R504C	SIDM01608	Endometrial Carcinoma	GDSC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.1111
p.R504C	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.1111
p.P508S	TCGA-AP-A1DK	UCEC	TCGA	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.2222
p.P508S	DO42033	UCEC	ICGC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.2222
p.D512V	TCGA-J7-8537	KIRP	TCGA	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.7785
p.D512V	DO48499	KIRP	ICGC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.7785
p.R504H	TCGA-V5-AASV	ESCA	TCGA	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.1111
p.E532A	TCGA-VQ-AA6D	STAD	TCGA	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.0556
p.E532A	DO222392	STAD	ICGC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.0556
p.E532K	TCGA-YC-A89H	BLCA	TCGA	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.0556
p.E532K	DO51948	BLCA	ICGC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.0556
p.S523R	DO229035	LICA	ICGC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.3056
p.R521Q	DO229059	LICA	ICGC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.6218
p.G524R	DO229061	LICA	ICGC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation rewiring degron network	0.2778
p.D512H	SIDM00623	Other Blood Cancers	GDSC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.7688
p.D512H	Mo-T	haematopoietic and lymphoid tissue	COSMIC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.7688
p.Y518C	SIDM00151	Ovarian Carcinoma	GDSC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.7087
p.Y518C	ACH-000966	Ovarian Cancer	CCLE	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.7087
p.Y518C	IGROV-1	ovary	COSMIC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.7087
p.N517Y	SIDM00814	Other Solid Cancers	GDSC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.5948
p.N517Y	ACH-001401	Adrenal Cancer	CCLE	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.5948
p.N517Y	SW13	adrenal gland	COSMIC	DSPKYNYSLRP	CBL_PTK	512:522	Mutation altering degron motif	0.5948

Kaplan plot for AARS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AARS2

UniProt ID: Q5JTZ9

Entrez ID: 57505

Protein name: Alanine--tRNA ligase, mitochondrial (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AARS2 in