DegronMD

Uniprot ID: Q5JTZ9

Source protein: Alanine--tRNA ligase, mitochondrial

Source gene: AARS2

Class: CBL_PTK

Location: 512:522

E3 ligase: CBL

DEGRON score: 0.994

ASA_SCORE: 72.6091

COIL: 0.7465

CONS_SCORE: 0.3812

DSS_SCORE: 0.5447

HELIX: 0.108

FCONS_SCORE: 1.1811

RIG_SCORE: 0.7088

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D512N	TCGA-18-3409	LUSC	TCGA	DSPKYNYSLRP	CBL_PTK	0.5821
p.D512N	DO26444	LUSC	ICGC	DSPKYNYSLRP	CBL_PTK	0.5821
p.S513N	TCGA-85-A4CN	LUSC	TCGA	DSPKYNYSLRP	CBL_PTK	0.5958
p.S513N	DO45510	LUSC	ICGC	DSPKYNYSLRP	CBL_PTK	0.5958
p.R504C	TCGA-AA-A02R	COAD	TCGA	DSPKYNYSLRP	CBL_PTK	0.1111
p.R504C	SIDM01608	Endometrial Carcinoma	GDSC	DSPKYNYSLRP	CBL_PTK	0.1111
p.R504C	ACH-000990	Endometrial/Uterine Cancer	CCLE	DSPKYNYSLRP	CBL_PTK	0.1111
p.P508S	TCGA-AP-A1DK	UCEC	TCGA	DSPKYNYSLRP	CBL_PTK	0.2222
p.P508S	DO42033	UCEC	ICGC	DSPKYNYSLRP	CBL_PTK	0.2222
p.D512V	TCGA-J7-8537	KIRP	TCGA	DSPKYNYSLRP	CBL_PTK	0.7785
p.D512V	DO48499	KIRP	ICGC	DSPKYNYSLRP	CBL_PTK	0.7785
p.R504H	TCGA-V5-AASV	ESCA	TCGA	DSPKYNYSLRP	CBL_PTK	0.1111
p.E532A	TCGA-VQ-AA6D	STAD	TCGA	DSPKYNYSLRP	CBL_PTK	0.0556
p.E532A	DO222392	STAD	ICGC	DSPKYNYSLRP	CBL_PTK	0.0556
p.E532K	TCGA-YC-A89H	BLCA	TCGA	DSPKYNYSLRP	CBL_PTK	0.0556
p.E532K	DO51948	BLCA	ICGC	DSPKYNYSLRP	CBL_PTK	0.0556
p.S523R	DO229035	LICA	ICGC	DSPKYNYSLRP	CBL_PTK	0.3056
p.R521Q	DO229059	LICA	ICGC	DSPKYNYSLRP	CBL_PTK	0.6218
p.G524R	DO229061	LICA	ICGC	DSPKYNYSLRP	CBL_PTK	0.2778
p.D512H	SIDM00623	Other Blood Cancers	GDSC	DSPKYNYSLRP	CBL_PTK	0.7688
p.D512H	Mo-T	haematopoietic_and_lymphoid_tissue	COSMIC	DSPKYNYSLRP	CBL_PTK	0.7688
p.Y518C	SIDM00151	Ovarian Carcinoma	GDSC	DSPKYNYSLRP	CBL_PTK	0.7087
p.Y518C	ACH-000966	Ovarian Cancer	CCLE	DSPKYNYSLRP	CBL_PTK	0.7087
p.Y518C	IGROV-1	ovary	COSMIC	DSPKYNYSLRP	CBL_PTK	0.7087
p.N517Y	SIDM00814	Other Solid Cancers	GDSC	DSPKYNYSLRP	CBL_PTK	0.5948
p.N517Y	ACH-001401	Adrenal Cancer	CCLE	DSPKYNYSLRP	CBL_PTK	0.5948
p.N517Y	SW13	adrenal_gland	COSMIC	DSPKYNYSLRP	CBL_PTK	0.5948

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JTZ9	Alanine--tRNA ligase, mitochondrial	CBL_PTK	512:522	DSPKYNYSLRP	CBL	0.994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSPKYNYSLRP

Degron related mutations and impact score

Drug responses associated with AARS2 mutations

All proteins holding degron of DSPKYNYSLRP