DegronMD - Q5JVL4(EFHC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R216Q	TCGA-CA-6718	COAD	TCGA	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.2778
p.R216Q	TCGA-E6-A1LX	UCEC	TCGA	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.2778
p.R216Q	DO7801	COAD	ICGC	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.2778
p.R216Q	DO229493	LAML	ICGC	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.2778
p.R216Q	DO41020	UCEC	ICGC	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.2778
p.R221C	TCGA-D9-A6EC	SKCM	TCGA	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1389
p.L220F	TCGA-DK-A6B6	BLCA	TCGA	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1667
p.L220F	DO48576	BLCA	ICGC	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1667
p.C220Y	DO47833	STAD	ICGC	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1667
p.E200Q	SIDM01953	Colorectal Carcinoma	GDSC	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.0833
p.R221H	SIDM00967	Ovarian Carcinoma	GDSC	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1389
p.R221H	SIDM00529	Breast Carcinoma	GDSC	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1389
p.R221H	SIDM00844	Burkitt's Lymphoma	GDSC	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1389
p.R221H	SIDM00257	Neuroblastoma	GDSC	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1389
p.R221H	SIDM00785	Acute Myeloid Leukemia	GDSC	LDPYTE	LIG_APCC_ABBA_1	209:214	Mutation rewiring degron network	0.1389

Kaplan plot for EFHC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EFHC1

UniProt ID: Q5JVL4

Entrez ID: 114327

Protein name: EF-hand domain-containing protein 1 (Myoclonin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EFHC1 in