DegronMD

Uniprot ID: Q5JVL4

Source protein: EF-hand domain-containing protein 1

Source gene: EFHC1

Class: LIG_APCC_ABBA_1

Location: 209:214

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6497

ASA_SCORE: 84.6667

COIL: 0.6013

CONS_SCORE: 0.6297

DSS_SCORE: 0.464

HELIX: 0.3787

FCONS_SCORE: 1.1316

RIG_SCORE: 0.7941

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R216Q	TCGA-CA-6718	COAD	TCGA	LDPYTE	LIG_APCC_ABBA_1	0.2778
p.R216Q	TCGA-E6-A1LX	UCEC	TCGA	LDPYTE	LIG_APCC_ABBA_1	0.2778
p.R216Q	DO7801	COAD	ICGC	LDPYTE	LIG_APCC_ABBA_1	0.2778
p.R216Q	DO229493	LAML	ICGC	LDPYTE	LIG_APCC_ABBA_1	0.2778
p.R216Q	DO41020	UCEC	ICGC	LDPYTE	LIG_APCC_ABBA_1	0.2778
p.R221C	TCGA-D9-A6EC	SKCM	TCGA	LDPYTE	LIG_APCC_ABBA_1	0.1389
p.L220F	TCGA-DK-A6B6	BLCA	TCGA	LDPYTE	LIG_APCC_ABBA_1	0.1667
p.L220F	DO48576	BLCA	ICGC	LDPYTE	LIG_APCC_ABBA_1	0.1667
p.C220Y	DO47833	STAD	ICGC	LDPYTE	LIG_APCC_ABBA_1	0.1667
p.E200Q	SIDM01953	Colorectal Carcinoma	GDSC	LDPYTE	LIG_APCC_ABBA_1	0.0833
p.R221H	SIDM00967	Ovarian Carcinoma	GDSC	LDPYTE	LIG_APCC_ABBA_1	0.1389
p.R221H	SIDM00529	Breast Carcinoma	GDSC	LDPYTE	LIG_APCC_ABBA_1	0.1389
p.R221H	SIDM00844	Burkitt's Lymphoma	GDSC	LDPYTE	LIG_APCC_ABBA_1	0.1389
p.R221H	SIDM00257	Neuroblastoma	GDSC	LDPYTE	LIG_APCC_ABBA_1	0.1389
p.R221H	SIDM00785	Acute Myeloid Leukemia	GDSC	LDPYTE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JVL4	EF-hand domain-containing protein 1	LIG_APCC_ABBA_1	209:214	LDPYTE	APC,CDC20,FZR1	0.6497	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons