DegronMD - Q5R3F8(ELFN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R253Q	TCGA-94-8490	LUSC	TCGA	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.1944
p.R253Q	TCGA-DU-6392	LGG	TCGA	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.1944
p.R253Q	DO22237	LGG	ICGC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.1944
p.R253Q	DO52021	LUSC	ICGC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.1944
p.E271D	TCGA-AP-A1E0	UCEC	TCGA	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.1111
p.E271D	DO43154	UCEC	ICGC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.1111
p.Q266R	TCGA-D9-A6EC	SKCM	TCGA	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.25
p.Q266R	DO50291	SKCM	ICGC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.25
p.S249L	TCGA-DM-A282	COAD	TCGA	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.0833
p.S249L	DO9058	COAD	ICGC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.0833
p.N272K	DO222926	BTCA	ICGC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.0833
p.V255M	DO50775	LICA	ICGC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.25
p.P258S	DO229462	SKCA	ICGC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation altering degron motif	0.6752
p.A265T	SIDM00572	Gastric Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.2778
p.V255L	SIDM01040	Ovarian Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.25
p.V255L	SIDM00781	Colorectal Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.25
p.V255L	SIDM00544	Neuroblastoma	GDSC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.25
p.V255L	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.25
p.V255L	SIDM01180	Hepatocellular Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.25
p.V255L	SIDM00008	Ovarian Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.25
p.V255L	SIDM00780	Colorectal Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.25
p.S262Y	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation altering degron motif	0.6009
p.S262Y	SIDM01664	Prostate Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation altering degron motif	0.6009
p.A265V	ACH-001570	Skin Cancer	CCLE	PTPYST	DEG_SCF_FBW7_1	258:263	Mutation rewiring degron network	0.2778

Kaplan plot for ELFN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ELFN2

UniProt ID: Q5R3F8

Entrez ID: 114794

Protein name: Protein phosphatase 1 regulatory subunit 29 (Extracellular leucine-rich repeat and fibronectin type III domain-containing protein 2) (Leucine-rich repeat and fibronectin type-III domain-containing protein 6) (Leucine-rich repeat-containing protein 62)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ELFN2 in