DegronMD

Uniprot ID: Q5R3F8

Source protein: Protein phosphatase 1 regulatory subunit 29

Source gene: ELFN2

Class: DEG_SCF_FBW7_1

Location: 258:263

E3 ligase: FBXW7

DEGRON score: 0.5078

ASA_SCORE: 77

COIL: 0.8652

CONS_SCORE: 0.4818

DSS_SCORE: 0.7434

HELIX: 0.0442

FCONS_SCORE: 0.8155

RIG_SCORE: 0.6221

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P258S	DO229462	SKCA	ICGC	PTPYST	DEG_SCF_FBW7_1	0.6752
p.S262Y	SIDM00721	Small Cell Lung Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	0.6009
p.S262Y	SIDM01664	Prostate Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	0.6009
p.A265T	SIDM00572	Gastric Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	0.2778
p.A265V	ACH-001570	Skin Cancer	CCLE	PTPYST	DEG_SCF_FBW7_1	0.2778
p.Q266R	TCGA-D9-A6EC	SKCM	TCGA	PTPYST	DEG_SCF_FBW7_1	0.25
p.Q266R	DO50291	SKCM	ICGC	PTPYST	DEG_SCF_FBW7_1	0.25
p.V255M	DO50775	LICA	ICGC	PTPYST	DEG_SCF_FBW7_1	0.25
p.V255L	SIDM01040	Ovarian Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	0.25
p.V255L	SIDM00781	Colorectal Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	0.25
p.V255L	SIDM00544	Neuroblastoma	GDSC	PTPYST	DEG_SCF_FBW7_1	0.25
p.V255L	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	0.25
p.V255L	SIDM01180	Hepatocellular Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	0.25
p.V255L	SIDM00008	Ovarian Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	0.25
p.V255L	SIDM00780	Colorectal Carcinoma	GDSC	PTPYST	DEG_SCF_FBW7_1	0.25
p.R253Q	TCGA-94-8490	LUSC	TCGA	PTPYST	DEG_SCF_FBW7_1	0.1944
p.R253Q	TCGA-DU-6392	LGG	TCGA	PTPYST	DEG_SCF_FBW7_1	0.1944
p.R253Q	DO22237	LGG	ICGC	PTPYST	DEG_SCF_FBW7_1	0.1944
p.R253Q	DO52021	LUSC	ICGC	PTPYST	DEG_SCF_FBW7_1	0.1944
p.E271D	TCGA-AP-A1E0	UCEC	TCGA	PTPYST	DEG_SCF_FBW7_1	0.1111
p.E271D	DO43154	UCEC	ICGC	PTPYST	DEG_SCF_FBW7_1	0.1111
p.S249L	TCGA-DM-A282	COAD	TCGA	PTPYST	DEG_SCF_FBW7_1	0.0833
p.S249L	DO9058	COAD	ICGC	PTPYST	DEG_SCF_FBW7_1	0.0833
p.N272K	DO222926	BTCA	ICGC	PTPYST	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5R3F8	Protein phosphatase 1 regulatory subunit 29	DEG_SCF_FBW7_1	258:263	PTPYST	FBXW7	0.5078	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons