DegronMD - Q5SRH9(TTC39A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P185S	TCGA-A5-A0G2	UCEC	TCGA	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1111
p.H184Y	TCGA-AB-2826	LAML	TCGA	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1389
p.R166H	DO224865	BRCA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.25
p.R166H	DO230346	COCA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.25
p.I185M	DO49964	CESC	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1111
p.F180I	DO233813	GACA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.25
p.P161Q	DO228934	LICA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1111
p.Q173K	DO228978	LICA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.6944
p.L172M	DO229032	LICA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.711
p.Q167H	DO232224	PBCA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.2778
p.E179K	SIDM00185	Melanoma	GDSC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.2778
p.E179K	SIDM00054	Pancreatic Carcinoma	GDSC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.2778
p.E179K	LB2518-MEL	skin	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.2778
p.H172R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.7133
p.H172R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.7133
p.A161T	SIDM01617	Endometrial Carcinoma	GDSC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1111
p.A161T	ACH-000994	Endometrial/Uterine Cancer	CCLE	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1111
p.H168R	ACH-001669	Leukemia	CCLE	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.3056
p.H168R	ACH-002238	Leukemia	CCLE	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.3056
p.H168R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.3056
p.E175K	ACH-002152	Skin Cancer	CCLE	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.7022
p.E175K	LB2518-MEL	skin	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.7022
p.P182L	RKN	ovary	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1944
p.P182L	NB(TU)1-10	autonomic ganglia	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1944
p.E178K	LB2518-MEL	skin	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.3056
p.P185L	RKN	ovary	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1111
p.P185L	NB(TU)1-10	autonomic ganglia	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation rewiring degron network	0.1111
p.H171R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	169:177	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTC39A

UniProt ID: Q5SRH9

Entrez ID: 22996

Protein name: Tetratricopeptide repeat protein 39A (TPR repeat protein 39A) (Differentially expressed in MCF7 with estradiol protein 6) (DEME-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTC39A in