DegronMD

Uniprot ID: Q5SRH9

Source protein: Tetratricopeptide repeat protein 39A

Source gene: TTC39A

Class: DEG_APCC_DBOX_1

Location: 169:177

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9027

ASA_SCORE: 61.9556

COIL: 0.455

CONS_SCORE: -111.0129

DSS_SCORE: 0.3456

HELIX: 0.4673

FCONS_SCORE: 2.4561

RIG_SCORE: 0.7871

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P185S	TCGA-A5-A0G2	UCEC	TCGA	GRQHLFLLQ	DEG_APCC_DBOX_1	0.1111
p.H184Y	TCGA-AB-2826	LAML	TCGA	GRQHLFLLQ	DEG_APCC_DBOX_1	0.1389
p.R166H	DO224865	BRCA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.25
p.R166H	DO230346	COCA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.25
p.I185M	DO49964	CESC	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.1111
p.F180I	DO233813	GACA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.25
p.P161Q	DO228934	LICA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.1111
p.Q173K	DO228978	LICA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.6944
p.L172M	DO229032	LICA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.711
p.Q167H	DO232224	PBCA	ICGC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.2778
p.E179K	SIDM00185	Melanoma	GDSC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.2778
p.E179K	SIDM00054	Pancreatic Carcinoma	GDSC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.2778
p.E179K	LB2518-MEL	skin	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.2778
p.H172R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.7133
p.H172R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.7133
p.A161T	SIDM01617	Endometrial Carcinoma	GDSC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.1111
p.A161T	ACH-000994	Endometrial/Uterine Cancer	CCLE	GRQHLFLLQ	DEG_APCC_DBOX_1	0.1111
p.H168R	ACH-001669	Leukemia	CCLE	GRQHLFLLQ	DEG_APCC_DBOX_1	0.3056
p.H168R	ACH-002238	Leukemia	CCLE	GRQHLFLLQ	DEG_APCC_DBOX_1	0.3056
p.H168R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.3056
p.E175K	ACH-002152	Skin Cancer	CCLE	GRQHLFLLQ	DEG_APCC_DBOX_1	0.7022
p.E175K	LB2518-MEL	skin	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.7022
p.P182L	RKN	ovary	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.1944
p.P182L	NB(TU)1-10	autonomic_ganglia	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.1944
p.E178K	LB2518-MEL	skin	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.3056
p.P185L	RKN	ovary	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.1111
p.P185L	NB(TU)1-10	autonomic_ganglia	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.1111
p.H171R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	GRQHLFLLQ	DEG_APCC_DBOX_1	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRQHLFLLQ

Degron related mutations and impact score

Drug responses associated with TTC39A mutations

All proteins holding degron of GRQHLFLLQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SRH9	Tetratricopeptide repeat protein 39A	DEG_APCC_DBOX_1	169:177	GRQHLFLLQ	APC,CDC20,FZR1	0.9027	More...