DegronMD - Q5SWA1(PPP1R15B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E246D	TCGA-22-5491	LUSC	TCGA	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.1389
p.E246D	DO26420	LUSC	ICGC	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.1389
p.H264R	TCGA-B5-A3FC	UCEC	TCGA	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.1667
p.H264R	DO41871	UCEC	ICGC	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.1667
p.V248L	TCGA-E9-A244	BRCA	TCGA	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.1944
p.V248L	DO5263	BRCA	ICGC	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.1944
p.R261K	SIDM00656	Burkitt's Lymphoma	GDSC	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.25
p.R261K	SIDM00641	Burkitt's Lymphoma	GDSC	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.25
p.R261K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.25
p.L260P	SIDM00014	Colorectal Carcinoma	GDSC	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.2778
p.L260P	LIM1215	large intestine	COSMIC	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.2778
p.G249D	SIDM01378	Ovarian Carcinoma	GDSC	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.2222
p.G249D	ACH-000646	Ovarian Cancer	CCLE	LTPESS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons