DegronMD

Uniprot ID: Q5SWA1

Source protein: Protein phosphatase 1 regulatory subunit 15B

Source gene: PPP1R15B

Class: DEG_SCF_FBW7_1

Location: 253:258

E3 ligase: FBXW7

DEGRON score: 0.9912

ASA_SCORE: 71.3

COIL: 0.736

CONS_SCORE: 0.6597

DSS_SCORE: 0.3436

HELIX: 0.1823

FCONS_SCORE: 1.4514

RIG_SCORE: 0.7321

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E246D	TCGA-22-5491	LUSC	TCGA	LTPESS	DEG_SCF_FBW7_1	0.1389
p.E246D	DO26420	LUSC	ICGC	LTPESS	DEG_SCF_FBW7_1	0.1389
p.H264R	TCGA-B5-A3FC	UCEC	TCGA	LTPESS	DEG_SCF_FBW7_1	0.1667
p.H264R	DO41871	UCEC	ICGC	LTPESS	DEG_SCF_FBW7_1	0.1667
p.V248L	TCGA-E9-A244	BRCA	TCGA	LTPESS	DEG_SCF_FBW7_1	0.1944
p.V248L	DO5263	BRCA	ICGC	LTPESS	DEG_SCF_FBW7_1	0.1944
p.R261K	SIDM00656	Burkitt's Lymphoma	GDSC	LTPESS	DEG_SCF_FBW7_1	0.25
p.R261K	SIDM00641	Burkitt's Lymphoma	GDSC	LTPESS	DEG_SCF_FBW7_1	0.25
p.R261K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LTPESS	DEG_SCF_FBW7_1	0.25
p.L260P	SIDM00014	Colorectal Carcinoma	GDSC	LTPESS	DEG_SCF_FBW7_1	0.2778
p.L260P	LIM1215	large_intestine	COSMIC	LTPESS	DEG_SCF_FBW7_1	0.2778
p.G249D	SIDM01378	Ovarian Carcinoma	GDSC	LTPESS	DEG_SCF_FBW7_1	0.2222
p.G249D	ACH-000646	Ovarian Cancer	CCLE	LTPESS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SWA1	Protein phosphatase 1 regulatory subunit 15B	DEG_SCF_FBW7_1	253:258	LTPESS	FBXW7	0.9912	More...
Q8IWQ3	Serine/threonine-protein kinase BRSK2	DEG_SCF_FBW7_1	508:513	LTPESS	FBXW7	0.9621	More...
Q8TDC3	Serine/threonine-protein kinase BRSK1	DEG_SCF_FBW7_1	582:587	LTPESS	FBXW7	0.9475	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons