DegronMD

Uniprot ID: Q8IWQ3

Source protein: Serine/threonine-protein kinase BRSK2

Source gene: BRSK2

Class: DEG_SCF_FBW7_1

Location: 508:513

E3 ligase: FBXW7

DEGRON score: 0.9621

ASA_SCORE: 82.4333

COIL: 0.9297

CONS_SCORE: 0.4866

DSS_SCORE: 0.5597

HELIX: 0.0468

FCONS_SCORE: 1.1169

RIG_SCORE: 0.6691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G517R	DO222564	ESCA	ICGC	LTPESS	DEG_SCF_FBW7_1	0.2222
p.T505M	DO51251	SKCM	ICGC	LTPESS	DEG_SCF_FBW7_1	0.25
p.A523V	SIDM00591	Oral Cavity Carcinoma	GDSC	LTPESS	DEG_SCF_FBW7_1	0.0556
p.T501M	ACH-001368	Esophageal Cancer	CCLE	LTPESS	DEG_SCF_FBW7_1	0.1389
p.S503Y	NCI-H650	lung	COSMIC	LTPESS	DEG_SCF_FBW7_1	0.1944

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01045	UCEC\|endometrium	p.P7fs*93 (No)	GDSC	XMD11-85h	219.324
SIDM00837	COREAD\|large_intestine	p.P673fs*12 (No)	GDSC	XMD11-85h	15.5664
SIDM00781	COREAD\|large_intestine	p.P76S (No)	GDSC	XMD11-85h	33.928
SIDM00498	COREAD\|large_intestine	p.V551M (No)	GDSC	XMD11-85h	80.644
SIDM00791	LCML\|chronic_myeloid_leukaemia	p.G415S (No)	GDSC	XMD11-85h	20.5073
SIDM00602	STAD\|stomach	p.L318R (No)	GDSC	XMD11-85h	131.3361
SIDM00085	GBM\|glioma	p.A641fs*5 (No)	GDSC	XMD11-85h	67.4106
SIDM01086	ALL\|leukemia	p.P673fs*12 (No)	GDSC	XMD11-85h	10.2477
SIDM00987	THCA\|thyroid	p.G663R (No)	GDSC	XMD11-85h	5.5729
SIDM00150	COREAD\|large_intestine	p.P672fs*6 (No)	GDSC	XMD11-85h	148.5934
SIDM00683	PRAD\|prostate	p.P672fs*6 (No)	GDSC	XMD11-85h	27.4782
SIDM00541	COREAD\|large_intestine	p.M306L (No)	GDSC	XMD11-85h	163.9314
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.A723T (No)	GDSC	XMD11-85h	23.7363
SIDM00373	UCEC\|endometrium	p.K539Q (No)	GDSC	XMD11-85h	6.9626
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.S481Y (No)	GDSC	XMD11-85h	149.8984
SIDM01169	OV\|ovary	p.P672fs*6 (No)	GDSC	XMD11-85h	110.8369
SIDM01027	ESCA\|oesophagus	p.S691R (No)	GDSC	XMD11-85h	43.4577

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SWA1	Protein phosphatase 1 regulatory subunit 15B	DEG_SCF_FBW7_1	253:258	LTPESS	FBXW7	0.9912	More...
Q8IWQ3	Serine/threonine-protein kinase BRSK2	DEG_SCF_FBW7_1	508:513	LTPESS	FBXW7	0.9621	More...
Q8TDC3	Serine/threonine-protein kinase BRSK1	DEG_SCF_FBW7_1	582:587	LTPESS	FBXW7	0.9475	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons