DegronMD - Q8TDC3(BRSK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A576T	TCGA-43-A475	LUSC	TCGA	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.1667
p.A576T	TCGA-DK-A6AW	BLCA	TCGA	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.1667
p.A576T	TCGA-EA-A3HS	CESC	TCGA	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.1667
p.G545V	TCGA-86-8674	LUAD	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.2222
p.G545V	TCGA-86-8674	LUAD	TCGA	PTGTPGTT	DEG_SCF_FBW7_1	528:535	Mutation rewiring degron network	0.0556
p.G542S	TCGA-93-A4JN	LUAD	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.1389
p.G542S	TCGA-93-A4JN	LUAD	TCGA	PTGTPGTT	DEG_SCF_FBW7_1	528:535	Mutation rewiring degron network	0.1389
p.Q572H	TCGA-95-7947	LUAD	TCGA	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.0556
p.R550M	TCGA-97-A4M7	LUAD	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation altering degron motif	0.8632
p.R550S	TCGA-97-A4M7	LUAD	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation altering degron motif	0.7427
p.P588S	TCGA-AP-A1DK	UCEC	TCGA	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.3056
p.P588S	SIDM00545	Melanoma	GDSC	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.3056
p.P588S	SIDM01175	Other Sarcomas	GDSC	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.3056
p.P588S	Mewo	skin	COSMIC	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.3056
p.P588S	SW684	soft tissue	COSMIC	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.3056
p.P540S	TCGA-BF-A9VF	SKCM	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.0833
p.P540S	TCGA-BF-A9VF	SKCM	TCGA	PTGTPGTT	DEG_SCF_FBW7_1	528:535	Mutation rewiring degron network	0.1944
p.G597E	TCGA-CV-A468	HNSC	TCGA	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.0556
p.P588Q	TCGA-D3-A2JC	SKCM	TCGA	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.3056
p.P588Q	SIDM00986	Head and Neck Carcinoma	GDSC	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.3056
p.P588Q	BHY	upper aerodigestive tract	COSMIC	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.3056
p.P564T	TCGA-D3-A3CE	SKCM	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.1389
p.P564T	TCGA-DK-A2I1	BLCA	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.1389
p.R565S	TCGA-D9-A148	SKCM	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.1111
p.P588T	TCGA-DA-A1I5	SKCM	TCGA	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.3056
p.R565C	TCGA-EE-A29L	SKCM	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.1111
p.E585K	TCGA-EE-A2A2	SKCM	TCGA	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation altering degron motif	0.591
p.R510C	SIDM02035	Colorectal Carcinoma	GDSC	PLHTPRAS	DEG_SCF_FBW7_1	520:527	Mutation rewiring degron network	0.0556
p.P537L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PLHTPRAS	DEG_SCF_FBW7_1	520:527	Mutation rewiring degron network	0.0556
p.P537L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PTGTPGTT	DEG_SCF_FBW7_1	528:535	Mutation rewiring degron network	0.2778
p.P537L	KYSE-220	oesophagus	COSMIC	PLHTPRAS	DEG_SCF_FBW7_1	520:527	Mutation rewiring degron network	0.0556
p.P537L	KYSE-220	oesophagus	COSMIC	PTGTPGTT	DEG_SCF_FBW7_1	528:535	Mutation rewiring degron network	0.2778
p.R510P	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	PLHTPRAS	DEG_SCF_FBW7_1	520:527	Mutation rewiring degron network	0.0556
p.F560L	SIDM00490	Glioma	GDSC	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.25
p.F560L	Becker	central nervous system	COSMIC	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation rewiring degron network	0.25
p.F576L	Becker	central nervous system	COSMIC	LTPESS	DEG_SCF_FBW7_1	582:587	Mutation rewiring degron network	0.1667
p.P553L	KYSE-220	oesophagus	COSMIC	WRSRLNSIR	DEG_APCC_DBOX_1	549:557	Mutation altering degron motif	0.7582

Kaplan plot for BRSK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRSK1

UniProt ID: Q8TDC3

Entrez ID: 84446

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRSK1 in