DegronMD

Uniprot ID: Q8TDC3

Source protein: Serine/threonine-protein kinase BRSK1

Source gene: BRSK1

Class: DEG_APCC_DBOX_1

Location: 549:557

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9539

ASA_SCORE: 99.6333

COIL: 0.6516

CONS_SCORE: 0.5362

DSS_SCORE: 0.5141

HELIX: 0.3056

FCONS_SCORE: 1.0214

RIG_SCORE: 0.7575

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G545V	TCGA-86-8674	LUAD	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	0.2222
p.G542S	TCGA-93-A4JN	LUAD	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	0.1389
p.R550M	TCGA-97-A4M7	LUAD	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	0.8632
p.R550S	TCGA-97-A4M7	LUAD	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	0.7427
p.P540S	TCGA-BF-A9VF	SKCM	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	0.0833
p.P564T	TCGA-D3-A3CE	SKCM	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	0.1389
p.P564T	TCGA-DK-A2I1	BLCA	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	0.1389
p.R565S	TCGA-D9-A148	SKCM	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	0.1111
p.R565C	TCGA-EE-A29L	SKCM	TCGA	WRSRLNSIR	DEG_APCC_DBOX_1	0.1111
p.F560L	SIDM00490	Glioma	GDSC	WRSRLNSIR	DEG_APCC_DBOX_1	0.25
p.F560L	Becker	central_nervous_system	COSMIC	WRSRLNSIR	DEG_APCC_DBOX_1	0.25
p.P553L	KYSE-220	oesophagus	COSMIC	WRSRLNSIR	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDC3	Serine/threonine-protein kinase BRSK1	DEG_APCC_DBOX_1	549:557	WRSRLNSIR	APC,CDC20,FZR1	0.9539	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons