DegronMD

Uniprot ID: Q8TDC3

Source protein: Serine/threonine-protein kinase BRSK1

Source gene: BRSK1

Class: DEG_SCF_FBW7_1

Location: 528:535

E3 ligase: FBXW7

DEGRON score: 0.9684

ASA_SCORE: 88.75

COIL: 0.9821

CONS_SCORE: 0.4339

DSS_SCORE: 0.8751

HELIX: 0.0069

FCONS_SCORE: 1.0036

RIG_SCORE: 0.4859

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G545V	TCGA-86-8674	LUAD	TCGA	PTGTPGTT	DEG_SCF_FBW7_1	0.0556
p.G542S	TCGA-93-A4JN	LUAD	TCGA	PTGTPGTT	DEG_SCF_FBW7_1	0.1389
p.P540S	TCGA-BF-A9VF	SKCM	TCGA	PTGTPGTT	DEG_SCF_FBW7_1	0.1944
p.P537L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PTGTPGTT	DEG_SCF_FBW7_1	0.2778
p.P537L	KYSE-220	oesophagus	COSMIC	PTGTPGTT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDC3	Serine/threonine-protein kinase BRSK1	DEG_SCF_FBW7_1	528:535	PTGTPGTT	FBXW7	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons