DegronMD

Uniprot ID: Q8TDC3

Source protein: Serine/threonine-protein kinase BRSK1

Source gene: BRSK1

Class: DEG_SCF_FBW7_1

Location: 582:587

E3 ligase: FBXW7

DEGRON score: 0.9475

ASA_SCORE: 84.8667

COIL: 0.9307

CONS_SCORE: 0.454

DSS_SCORE: 0.5192

HELIX: 0.0493

FCONS_SCORE: 0.9888

RIG_SCORE: 0.6626

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A576T	TCGA-43-A475	LUSC	TCGA	LTPESS	DEG_SCF_FBW7_1	0.1667
p.A576T	TCGA-DK-A6AW	BLCA	TCGA	LTPESS	DEG_SCF_FBW7_1	0.1667
p.A576T	TCGA-EA-A3HS	CESC	TCGA	LTPESS	DEG_SCF_FBW7_1	0.1667
p.Q572H	TCGA-95-7947	LUAD	TCGA	LTPESS	DEG_SCF_FBW7_1	0.0556
p.P588S	TCGA-AP-A1DK	UCEC	TCGA	LTPESS	DEG_SCF_FBW7_1	0.3056
p.P588S	SIDM00545	Melanoma	GDSC	LTPESS	DEG_SCF_FBW7_1	0.3056
p.P588S	SIDM01175	Other Sarcomas	GDSC	LTPESS	DEG_SCF_FBW7_1	0.3056
p.P588S	Mewo	skin	COSMIC	LTPESS	DEG_SCF_FBW7_1	0.3056
p.P588S	SW684	soft_tissue	COSMIC	LTPESS	DEG_SCF_FBW7_1	0.3056
p.G597E	TCGA-CV-A468	HNSC	TCGA	LTPESS	DEG_SCF_FBW7_1	0.0556
p.P588Q	TCGA-D3-A2JC	SKCM	TCGA	LTPESS	DEG_SCF_FBW7_1	0.3056
p.P588Q	SIDM00986	Head and Neck Carcinoma	GDSC	LTPESS	DEG_SCF_FBW7_1	0.3056
p.P588Q	BHY	upper_aerodigestive_tract	COSMIC	LTPESS	DEG_SCF_FBW7_1	0.3056
p.P588T	TCGA-DA-A1I5	SKCM	TCGA	LTPESS	DEG_SCF_FBW7_1	0.3056
p.E585K	TCGA-EE-A2A2	SKCM	TCGA	LTPESS	DEG_SCF_FBW7_1	0.591
p.F576L	Becker	central_nervous_system	COSMIC	LTPESS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SWA1	Protein phosphatase 1 regulatory subunit 15B	DEG_SCF_FBW7_1	253:258	LTPESS	FBXW7	0.9912	More...
Q8IWQ3	Serine/threonine-protein kinase BRSK2	DEG_SCF_FBW7_1	508:513	LTPESS	FBXW7	0.9621	More...
Q8TDC3	Serine/threonine-protein kinase BRSK1	DEG_SCF_FBW7_1	582:587	LTPESS	FBXW7	0.9475	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons