DegronMD - Q8IWQ3(BRSK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R444W	TCGA-06-5416	GBM	TCGA	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.8634
p.R444W	DO10880	GBM	ICGC	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.8634
p.T435M	TCGA-19-5956	GBM	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation altering degron motif	0.7423
p.T435M	TCGA-FF-8043	DLBC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation altering degron motif	0.7423
p.T435M	DO222308	DLBC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation altering degron motif	0.7423
p.T435M	DO13863	GBM	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation altering degron motif	0.7423
p.S433R	TCGA-43-3920	LUSC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation altering degron motif	0.7427
p.S433R	DO26445	LUSC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation altering degron motif	0.7427
p.E448K	TCGA-55-8205	LUAD	TCGA	PVHTPKES	DEG_SCF_FBW7_1	448:455	Mutation altering degron motif	0.7022
p.E448K	TCGA-DK-AA6S	BLCA	TCGA	PVHTPKES	DEG_SCF_FBW7_1	448:455	Mutation altering degron motif	0.7022
p.E448K	DO219007	BLCA	ICGC	PVHTPKES	DEG_SCF_FBW7_1	448:455	Mutation altering degron motif	0.7022
p.E448K	DO48884	LUAD	ICGC	PVHTPKES	DEG_SCF_FBW7_1	448:455	Mutation altering degron motif	0.7022
p.R426C	TCGA-66-2759	LUSC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation blocking phosphorylation signal	0.7222
p.R426C	DO27326	LUSC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation blocking phosphorylation signal	0.7222
p.S428F	TCGA-AP-A059	UCEC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation altering degron motif	0.7982
p.S428F	DO41361	UCEC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation altering degron motif	0.7982
p.R445Q	TCGA-AX-A2HC	UCEC	TCGA	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.7329
p.R445Q	DO41572	UCEC	ICGC	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.7329
p.R445Q	SIDM01051	Ovarian Carcinoma	GDSC	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.7329
p.R445Q	EFO-27	ovary	COSMIC	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.7329
p.A450T	TCGA-AX-A2HD	UCEC	TCGA	PVHTPKES	DEG_SCF_FBW7_1	448:455	Mutation altering degron motif	0.7139
p.A450T	DO42608	UCEC	ICGC	PVHTPKES	DEG_SCF_FBW7_1	448:455	Mutation altering degron motif	0.7139
p.A443V	TCGA-BG-A221	UCEC	TCGA	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.6936
p.A443V	DO231744	LINC	ICGC	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.6936
p.A443V	DO42384	UCEC	ICGC	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.6936
p.A443V	SIDM02015	Colorectal Carcinoma	GDSC	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.6936
p.R423W	TCGA-BR-4201	STAD	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation blocking phosphorylation signal	0.6389
p.R423W	DO38707	STAD	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation blocking phosphorylation signal	0.6389
p.I459M	TCGA-CV-A6K2	HNSC	TCGA	PAGTPNPT	DEG_SCF_FBW7_1	456:463	Mutation altering degron motif	0.7618
p.I459M	DO52079	HNSC	ICGC	PAGTPNPT	DEG_SCF_FBW7_1	456:463	Mutation altering degron motif	0.7618
p.P474H	TCGA-EA-A5ZF	CESC	TCGA	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.3056
p.P474H	DO48976	CESC	ICGC	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.3056
p.R475Q	TCGA-EE-A2A6	SKCM	TCGA	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.7329
p.R475Q	DO37591	SKCM	ICGC	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.7329
p.P440Q	TCGA-ER-A19P	SKCM	TCGA	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.7035
p.P440Q	DO47623	SKCM	ICGC	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation altering degron motif	0.7035
p.R418W	TCGA-FI-A2D0	UCEC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation rewiring degron network	0.0556
p.R418W	DO43891	UCEC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation rewiring degron network	0.0556
p.S433I	TCGA-FI-A2D0	UCEC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation altering degron motif	0.7341
p.S433I	DO43891	UCEC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation altering degron motif	0.7341
p.L471R	TCGA-G2-AA3C	BLCA	TCGA	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.2222
p.L471R	TCGA-G2-AA3C	BLCA	TCGA	PAGTPNPT	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.1111
p.L471R	DO51883	BLCA	ICGC	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.2222
p.L471R	DO51883	BLCA	ICGC	PAGTPNPT	DEG_SCF_FBW7_1	456:463	Mutation rewiring degron network	0.1111
p.R457Q	TCGA-HU-A4GT	STAD	TCGA	PAGTPNPT	DEG_SCF_FBW7_1	456:463	Mutation altering degron motif	0.7329
p.R457Q	DO48020	STAD	ICGC	PAGTPNPT	DEG_SCF_FBW7_1	456:463	Mutation altering degron motif	0.7329
p.A420T	DO227906	COCA	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation rewiring degron network	0.1111
p.S439F	DO50396	ESAD	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation blocking phosphorylation signal	0.6667
p.S439F	DO50396	ESAD	ICGC	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation blocking phosphorylation signal	0.75
p.S439F	DO50396	ESAD	ICGC	PVHTPKES	DEG_SCF_FBW7_1	448:455	Mutation blocking phosphorylation signal	0.5278
p.G517R	DO222564	ESCA	ICGC	LTPESS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.2222
p.R422W	DO233167	GACA	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation rewiring degron network	0.1667
p.V434M	DO233624	GACA	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation altering degron motif	0.7208
p.R426H	DO233731	GACA	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation blocking phosphorylation signal	0.7222
p.R418L	DO229034	LICA	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation rewiring degron network	0.0556
p.S427I	DO27349	LUSC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation blocking phosphorylation signal	0.75
p.T505M	DO51251	SKCM	ICGC	LTPESS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.25
p.F426I	DO43907	UCEC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation blocking phosphorylation signal	0.7222
p.G461S	SIDM00791	Chronic Myelogenous Leukemia	GDSC	PAGTPNPT	DEG_SCF_FBW7_1	456:463	Mutation altering degron motif	0.6993
p.G461S	K-562	haematopoietic and lymphoid tissue	COSMIC	PAGTPNPT	DEG_SCF_FBW7_1	456:463	Mutation altering degron motif	0.6993
p.G420C	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation rewiring degron network	0.1111
p.G420C	NCI-H2342	lung	COSMIC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation rewiring degron network	0.1111
p.A523V	SIDM00591	Oral Cavity Carcinoma	GDSC	LTPESS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.0556
p.G437D	SIDM01608	Endometrial Carcinoma	GDSC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation rewiring degron network	0.2778
p.G437D	SIDM01608	Endometrial Carcinoma	GDSC	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation rewiring degron network	0.25
p.S481Y	ACH-000945	Lung Cancer	CCLE	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.712
p.S481Y	NCI-H650	lung	COSMIC	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.712
p.T501M	ACH-001368	Esophageal Cancer	CCLE	LTPESS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.1389
p.A477V	ACH-001558	Lung Cancer	CCLE	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.5825
p.A477V	ACH-002045	Head and Neck Cancer	CCLE	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.5825
p.K479Q	SNG-M	endometrium	COSMIC	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation altering degron motif	0.6944
p.S503Y	NCI-H650	lung	COSMIC	LTPESS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.1944
p.V491M	SNU-C5	large intestine	COSMIC	WRARLNSIK	DEG_APCC_DBOX_1	475:483	Mutation rewiring degron network	0.1111
p.G437S	K-562	haematopoietic and lymphoid tissue	COSMIC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation rewiring degron network	0.2778
p.G437S	K-562	haematopoietic and lymphoid tissue	COSMIC	PLPTPKGT	DEG_SCF_FBW7_1	440:447	Mutation rewiring degron network	0.25
p.S421Y	NCI-H650	lung	COSMIC	PRVTPHPS	DEG_SCF_FBW7_1	428:435	Mutation rewiring degron network	0.1389

Kaplan plot for BRSK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRSK2

UniProt ID: Q8IWQ3

Entrez ID: 9024

Protein name: Serine/threonine-protein kinase BRSK2 (EC 2.7.11.1) (Brain-selective kinase 2) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 2) (BR serine/threonine-protein kinase 2) (Serine/threonine-protein kinase 29) (Serine/threonine-protein kinase SAD-A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRSK2 in