DegronMD

Uniprot ID: Q8IWQ3

Source protein: Serine/threonine-protein kinase BRSK2

Source gene: BRSK2

Class: DEG_APCC_DBOX_1

Location: 475:483

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6342

ASA_SCORE: 105.8444

COIL: 0.7664

CONS_SCORE: 0.4842

DSS_SCORE: 0.4806

HELIX: 0.1899

FCONS_SCORE: 0.9433

RIG_SCORE: 0.7459

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P474H	TCGA-EA-A5ZF	CESC	TCGA	WRARLNSIK	DEG_APCC_DBOX_1	0.3056
p.P474H	DO48976	CESC	ICGC	WRARLNSIK	DEG_APCC_DBOX_1	0.3056
p.R475Q	TCGA-EE-A2A6	SKCM	TCGA	WRARLNSIK	DEG_APCC_DBOX_1	0.7329
p.R475Q	DO37591	SKCM	ICGC	WRARLNSIK	DEG_APCC_DBOX_1	0.7329
p.L471R	TCGA-G2-AA3C	BLCA	TCGA	WRARLNSIK	DEG_APCC_DBOX_1	0.2222
p.L471R	DO51883	BLCA	ICGC	WRARLNSIK	DEG_APCC_DBOX_1	0.2222
p.S481Y	ACH-000945	Lung Cancer	CCLE	WRARLNSIK	DEG_APCC_DBOX_1	0.712
p.S481Y	NCI-H650	lung	COSMIC	WRARLNSIK	DEG_APCC_DBOX_1	0.712
p.A477V	ACH-001558	Lung Cancer	CCLE	WRARLNSIK	DEG_APCC_DBOX_1	0.5825
p.A477V	ACH-002045	Head and Neck Cancer	CCLE	WRARLNSIK	DEG_APCC_DBOX_1	0.5825
p.K479Q	SNG-M	endometrium	COSMIC	WRARLNSIK	DEG_APCC_DBOX_1	0.6944
p.V491M	SNU-C5	large_intestine	COSMIC	WRARLNSIK	DEG_APCC_DBOX_1	0.1111

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01045	UCEC\|endometrium	p.P7fs*93 (No)	GDSC	XMD11-85h	219.324
SIDM00837	COREAD\|large_intestine	p.P673fs*12 (No)	GDSC	XMD11-85h	15.5664
SIDM00781	COREAD\|large_intestine	p.P76S (No)	GDSC	XMD11-85h	33.928
SIDM00498	COREAD\|large_intestine	p.V551M (No)	GDSC	XMD11-85h	80.644
SIDM00791	LCML\|chronic_myeloid_leukaemia	p.G415S (No)	GDSC	XMD11-85h	20.5073
SIDM00602	STAD\|stomach	p.L318R (No)	GDSC	XMD11-85h	131.3361
SIDM00085	GBM\|glioma	p.A641fs*5 (No)	GDSC	XMD11-85h	67.4106
SIDM01086	ALL\|leukemia	p.P673fs*12 (No)	GDSC	XMD11-85h	10.2477
SIDM00987	THCA\|thyroid	p.G663R (No)	GDSC	XMD11-85h	5.5729
SIDM00150	COREAD\|large_intestine	p.P672fs*6 (No)	GDSC	XMD11-85h	148.5934
SIDM00683	PRAD\|prostate	p.P672fs*6 (No)	GDSC	XMD11-85h	27.4782
SIDM00541	COREAD\|large_intestine	p.M306L (No)	GDSC	XMD11-85h	163.9314
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.A723T (No)	GDSC	XMD11-85h	23.7363
SIDM00373	UCEC\|endometrium	p.K539Q (No)	GDSC	XMD11-85h	6.9626
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.S481Y (Yes)	GDSC	XMD11-85h	149.8984
SIDM01169	OV\|ovary	p.P672fs*6 (No)	GDSC	XMD11-85h	110.8369
SIDM01027	ESCA\|oesophagus	p.S691R (No)	GDSC	XMD11-85h	43.4577

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWQ3	Serine/threonine-protein kinase BRSK2	DEG_APCC_DBOX_1	475:483	WRARLNSIK	APC,CDC20,FZR1	0.6342	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons