DegronMD

Uniprot ID: Q8IWQ3

Source protein: Serine/threonine-protein kinase BRSK2

Source gene: BRSK2

Class: DEG_SCF_FBW7_1

Location: 428:435

E3 ligase: FBXW7

DEGRON score: 0.9706

ASA_SCORE: 107.5375

COIL: 0.9716

CONS_SCORE: 0.3819

DSS_SCORE: 0.798

HELIX: 0.0074

FCONS_SCORE: 0.8775

RIG_SCORE: 0.504

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T435M	TCGA-19-5956	GBM	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	0.7423
p.T435M	TCGA-FF-8043	DLBC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	0.7423
p.T435M	DO222308	DLBC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.7423
p.T435M	DO13863	GBM	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.7423
p.S433R	TCGA-43-3920	LUSC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	0.7427
p.S433R	DO26445	LUSC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.7427
p.R426C	TCGA-66-2759	LUSC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	0.7222
p.R426C	DO27326	LUSC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.7222
p.S428F	TCGA-AP-A059	UCEC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	0.7982
p.S428F	DO41361	UCEC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.7982
p.R423W	TCGA-BR-4201	STAD	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	0.6389
p.R423W	DO38707	STAD	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.6389
p.R418W	TCGA-FI-A2D0	UCEC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	0.0556
p.R418W	DO43891	UCEC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.0556
p.S433I	TCGA-FI-A2D0	UCEC	TCGA	PRVTPHPS	DEG_SCF_FBW7_1	0.7341
p.S433I	DO43891	UCEC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.7341
p.A420T	DO227906	COCA	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.1111
p.S439F	DO50396	ESAD	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.6667
p.R422W	DO233167	GACA	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.1667
p.V434M	DO233624	GACA	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.7208
p.R426H	DO233731	GACA	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.7222
p.R418L	DO229034	LICA	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.0556
p.S427I	DO27349	LUSC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.75
p.F426I	DO43907	UCEC	ICGC	PRVTPHPS	DEG_SCF_FBW7_1	0.7222
p.G420C	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PRVTPHPS	DEG_SCF_FBW7_1	0.1111
p.G420C	NCI-H2342	lung	COSMIC	PRVTPHPS	DEG_SCF_FBW7_1	0.1111
p.G437D	SIDM01608	Endometrial Carcinoma	GDSC	PRVTPHPS	DEG_SCF_FBW7_1	0.2778
p.G437S	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	PRVTPHPS	DEG_SCF_FBW7_1	0.2778
p.S421Y	NCI-H650	lung	COSMIC	PRVTPHPS	DEG_SCF_FBW7_1	0.1389

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01045	UCEC\|endometrium	p.P7fs*93 (No)	GDSC	XMD11-85h	219.324
SIDM00837	COREAD\|large_intestine	p.P673fs*12 (No)	GDSC	XMD11-85h	15.5664
SIDM00781	COREAD\|large_intestine	p.P76S (No)	GDSC	XMD11-85h	33.928
SIDM00498	COREAD\|large_intestine	p.V551M (No)	GDSC	XMD11-85h	80.644
SIDM00791	LCML\|chronic_myeloid_leukaemia	p.G415S (No)	GDSC	XMD11-85h	20.5073
SIDM00602	STAD\|stomach	p.L318R (No)	GDSC	XMD11-85h	131.3361
SIDM00085	GBM\|glioma	p.A641fs*5 (No)	GDSC	XMD11-85h	67.4106
SIDM01086	ALL\|leukemia	p.P673fs*12 (No)	GDSC	XMD11-85h	10.2477
SIDM00987	THCA\|thyroid	p.G663R (No)	GDSC	XMD11-85h	5.5729
SIDM00150	COREAD\|large_intestine	p.P672fs*6 (No)	GDSC	XMD11-85h	148.5934
SIDM00683	PRAD\|prostate	p.P672fs*6 (No)	GDSC	XMD11-85h	27.4782
SIDM00541	COREAD\|large_intestine	p.M306L (No)	GDSC	XMD11-85h	163.9314
SIDM00438	UNCLASSIFIED\|B_cell_leukemia	p.A723T (No)	GDSC	XMD11-85h	23.7363
SIDM00373	UCEC\|endometrium	p.K539Q (No)	GDSC	XMD11-85h	6.9626
SIDM01124	LUAD\|lung_NSCLC_adenocarcinoma	p.S481Y (No)	GDSC	XMD11-85h	149.8984
SIDM01169	OV\|ovary	p.P672fs*6 (No)	GDSC	XMD11-85h	110.8369
SIDM01027	ESCA\|oesophagus	p.S691R (No)	GDSC	XMD11-85h	43.4577

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRVTPHPS

Degron related mutations and impact score

Drug responses associated with BRSK2 mutations

All proteins holding degron of PRVTPHPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWQ3	Serine/threonine-protein kinase BRSK2	DEG_SCF_FBW7_1	428:435	PRVTPHPS	FBXW7	0.9706	More...