DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PLPTPKGT
Uniprot ID:
Q8IWQ3
Source protein:
Serine/threonine-protein kinase BRSK2
Source gene:
BRSK2
Class:
DEG_SCF_FBW7_1
Location:
440:447
E3 ligase:
FBXW7
DEGRON score:
0.9978
ASA_SCORE:
104.2
COIL:
0.9693
CONS_SCORE:
0.4443
DSS_SCORE:
0.8221
HELIX:
0.0106
FCONS_SCORE:
1.1088
RIG_SCORE:
0.4696
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R444W
TCGA-06-5416
GBM
TCGA
PLPTPKGT
DEG_SCF_FBW7_1
0.8634
p.R444W
DO10880
GBM
ICGC
PLPTPKGT
DEG_SCF_FBW7_1
0.8634
p.R445Q
TCGA-AX-A2HC
UCEC
TCGA
PLPTPKGT
DEG_SCF_FBW7_1
0.7329
p.R445Q
DO41572
UCEC
ICGC
PLPTPKGT
DEG_SCF_FBW7_1
0.7329
p.R445Q
SIDM01051
Ovarian Carcinoma
GDSC
PLPTPKGT
DEG_SCF_FBW7_1
0.7329
p.R445Q
EFO-27
ovary
COSMIC
PLPTPKGT
DEG_SCF_FBW7_1
0.7329
p.A443V
TCGA-BG-A221
UCEC
TCGA
PLPTPKGT
DEG_SCF_FBW7_1
0.6936
p.A443V
DO231744
LINC
ICGC
PLPTPKGT
DEG_SCF_FBW7_1
0.6936
p.A443V
DO42384
UCEC
ICGC
PLPTPKGT
DEG_SCF_FBW7_1
0.6936
p.A443V
SIDM02015
Colorectal Carcinoma
GDSC
PLPTPKGT
DEG_SCF_FBW7_1
0.6936
p.P440Q
TCGA-ER-A19P
SKCM
TCGA
PLPTPKGT
DEG_SCF_FBW7_1
0.7035
p.P440Q
DO47623
SKCM
ICGC
PLPTPKGT
DEG_SCF_FBW7_1
0.7035
p.S439F
DO50396
ESAD
ICGC
PLPTPKGT
DEG_SCF_FBW7_1
0.75
p.G437D
SIDM01608
Endometrial Carcinoma
GDSC
PLPTPKGT
DEG_SCF_FBW7_1
0.25
p.G437S
K-562
haematopoietic_and_lymphoid_tissue
COSMIC
PLPTPKGT
DEG_SCF_FBW7_1
0.25
Drug responses associated with BRSK2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
SIDM01045
UCEC|endometrium
p.P7fs*93 (No)
GDSC
XMD11-85h
219.324
SIDM00837
COREAD|large_intestine
p.P673fs*12 (No)
GDSC
XMD11-85h
15.5664
SIDM00781
COREAD|large_intestine
p.P76S (No)
GDSC
XMD11-85h
33.928
SIDM00498
COREAD|large_intestine
p.V551M (No)
GDSC
XMD11-85h
80.644
SIDM00791
LCML|chronic_myeloid_leukaemia
p.G415S (No)
GDSC
XMD11-85h
20.5073
SIDM00602
STAD|stomach
p.L318R (No)
GDSC
XMD11-85h
131.3361
SIDM00085
GBM|glioma
p.A641fs*5 (No)
GDSC
XMD11-85h
67.4106
SIDM01086
ALL|leukemia
p.P673fs*12 (No)
GDSC
XMD11-85h
10.2477
SIDM00987
THCA|thyroid
p.G663R (No)
GDSC
XMD11-85h
5.5729
SIDM00150
COREAD|large_intestine
p.P672fs*6 (No)
GDSC
XMD11-85h
148.5934
SIDM00683
PRAD|prostate
p.P672fs*6 (No)
GDSC
XMD11-85h
27.4782
SIDM00541
COREAD|large_intestine
p.M306L (No)
GDSC
XMD11-85h
163.9314
SIDM00438
UNCLASSIFIED|B_cell_leukemia
p.A723T (No)
GDSC
XMD11-85h
23.7363
SIDM00373
UCEC|endometrium
p.K539Q (No)
GDSC
XMD11-85h
6.9626
SIDM01124
LUAD|lung_NSCLC_adenocarcinoma
p.S481Y (No)
GDSC
XMD11-85h
149.8984
SIDM01169
OV|ovary
p.P672fs*6 (No)
GDSC
XMD11-85h
110.8369
SIDM01027
ESCA|oesophagus
p.S691R (No)
GDSC
XMD11-85h
43.4577
All proteins holding degron of PLPTPKGT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IWQ3
Serine/threonine-protein kinase BRSK2
DEG_SCF_FBW7_1
440:447
PLPTPKGT
FBXW7
0.9978
More...