DegronMD

Uniprot ID: Q8TDC3

Source protein: Serine/threonine-protein kinase BRSK1

Source gene: BRSK1

Class: DEG_SCF_FBW7_1

Location: 520:527

E3 ligase: FBXW7

DEGRON score: 0.9804

ASA_SCORE: 100.3125

COIL: 0.9618

CONS_SCORE: 0.4114

DSS_SCORE: 0.8648

HELIX: 0.0155

FCONS_SCORE: 0.9663

RIG_SCORE: 0.5588

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R510C	SIDM02035	Colorectal Carcinoma	GDSC	PLHTPRAS	DEG_SCF_FBW7_1	0.0556
p.P537L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PLHTPRAS	DEG_SCF_FBW7_1	0.0556
p.P537L	KYSE-220	oesophagus	COSMIC	PLHTPRAS	DEG_SCF_FBW7_1	0.0556
p.R510P	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	PLHTPRAS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDC3	Serine/threonine-protein kinase BRSK1	DEG_SCF_FBW7_1	520:527	PLHTPRAS	FBXW7	0.9804	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons