DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
C9orf50
UniProt ID:
Q5SZB4
Entrez ID:
375759
Protein name:
Uncharacterized protein C9orf50
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
C9orf50
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.R88Q
DO230347
COCA
ICGC
KRGLLRSLL
DEG_APCC_DBOX_1
93:101
Mutation rewiring degron network
0.1944
p.R88Q
DO234389
ESAD
ICGC
KRGLLRSLL
DEG_APCC_DBOX_1
93:101
Mutation rewiring degron network
0.1944
p.R88Q
DO233118
GACA
ICGC
KRGLLRSLL
DEG_APCC_DBOX_1
93:101
Mutation rewiring degron network
0.1944
p.T85S
DO233864
GACA
ICGC
KRGLLRSLL
DEG_APCC_DBOX_1
93:101
Mutation rewiring degron network
0.1111
p.R92Q
DO38727
STAD
ICGC
KRGLLRSLL
DEG_APCC_DBOX_1
93:101
Mutation rewiring degron network
0.3056
p.S99Y
DO229257
THCA
ICGC
KRGLLRSLL
DEG_APCC_DBOX_1
93:101
Mutation altering degron motif
0.6009
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for C9orf50 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc