DegronMD

Uniprot ID: Q5SZB4

Source protein: Uncharacterized protein C9orf50

Source gene: C9orf50

Class: DEG_APCC_DBOX_1

Location: 93:101

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5475

ASA_SCORE: 88.4778

COIL: 0.6111

CONS_SCORE: 0.6986

DSS_SCORE: 0.4594

HELIX: 0.3308

FCONS_SCORE: 1.2619

RIG_SCORE: 0.7505

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R88Q	DO230347	COCA	ICGC	KRGLLRSLL	DEG_APCC_DBOX_1	0.1944
p.R88Q	DO234389	ESAD	ICGC	KRGLLRSLL	DEG_APCC_DBOX_1	0.1944
p.R88Q	DO233118	GACA	ICGC	KRGLLRSLL	DEG_APCC_DBOX_1	0.1944
p.T85S	DO233864	GACA	ICGC	KRGLLRSLL	DEG_APCC_DBOX_1	0.1111
p.R92Q	DO38727	STAD	ICGC	KRGLLRSLL	DEG_APCC_DBOX_1	0.3056
p.S99Y	DO229257	THCA	ICGC	KRGLLRSLL	DEG_APCC_DBOX_1	0.6009

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SZB4	Uncharacterized protein C9orf50	DEG_APCC_DBOX_1	93:101	KRGLLRSLL	APC,CDC20,FZR1	0.5475	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons