SPOUT1
UniProt ID: Q5T280
Entrez ID: 51490
Protein name: Putative methyltransferase C9orf114 (EC 2.1.1.-) (Centromere protein 32) (CENP-32) (Kinetochore-associated protein) (SPOUT domain-containing methyltransferase 1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to ...
FUNCTION: Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325). Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (PubMed:28431233). {ECO:0000269|PubMed:20813266, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:28431233}.
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GO - Biological processes (BP):
cell cycle [GO:0007049]; cell division [GO:0051301]; maintenance of centrosome location [GO:0051661]; methylation [GO:0032259]; posttranscriptional regulation of gene expression [GO:0010608]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]...
cell cycle [GO:0007049]; cell division [GO:0051301]; maintenance of centrosome location [GO:0051661]; methylation [GO:0032259]; posttranscriptional regulation of gene expression [GO:0010608]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]
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GO - Molecular function (MF):
methyltransferase activity [GO:0008168]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]...
methyltransferase activity [GO:0008168]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; spindle pole centrosome [GO:0031616]...
cytoplasm [GO:0005737]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; spindle pole centrosome [GO:0031616]
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SPOUT1
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*NOTE: the Kaplan plots were collected from OncoLnc