DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
IVVFDE
Uniprot ID:
Q5T280
Source protein:
Putative methyltransferase C9orf114
Source gene:
SPOUT1
Class:
LIG_APCC_ABBA_1
Location:
112:117
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5946
ASA_SCORE:
18.3833
COIL:
0.1957
CONS_SCORE:
0.7014
DSS_SCORE:
0.0803
HELIX:
0.0078
FCONS_SCORE:
1.3713
RIG_SCORE:
0.9458
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V114A
SIDM00537
Colorectal Carcinoma
GDSC
IVVFDE
LIG_APCC_ABBA_1
0.6936
p.V114A
GP5d
large_intestine
COSMIC
IVVFDE
LIG_APCC_ABBA_1
0.6936
Drug responses associated with SPOUT1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IVVFDE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5T280
Putative methyltransferase C9orf114
LIG_APCC_ABBA_1
112:117
IVVFDE
APC,CDC20,FZR1
0.5946
More...