DegronMD - Q5T481(RBM20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M1113I	TCGA-A2-A1FZ	BRCA	TCGA	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.1944
p.M1113I	DO2770	BRCA	ICGC	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.1944
p.S1115Y	TCGA-AN-A046	BRCA	TCGA	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation blocking phosphorylation signal	0.5833
p.S1115Y	DO1285	BRCA	ICGC	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation blocking phosphorylation signal	0.5833
p.S1115Y	DO8898	COAD	ICGC	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation blocking phosphorylation signal	0.5833
p.S1115Y	DO8730	COAD	ICGC	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation blocking phosphorylation signal	0.5833
p.E1101G	TCGA-D1-A16N	UCEC	TCGA	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.3056
p.E1101G	DO43771	UCEC	ICGC	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.3056
p.V1111M	SIDM00607	Glioblastoma	GDSC	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.25
p.V1111M	SIDM00245	Small Cell Lung Carcinoma	GDSC	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.25
p.V1111M	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.25
p.V1111M	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.25
p.V1111M	ACH-000261	Lung Cancer	CCLE	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.25
p.V1111M	ACH-000561	Esophageal Cancer	CCLE	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.25
p.V1111M	ACH-000622	Brain Cancer	CCLE	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.25
p.V1111M	ACH-000865	Esophageal Cancer	CCLE	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.25
p.V1111M	ACH-001036	Leukemia	CCLE	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.25
p.V1111M	ACH-001207	Non-Cancerous	CCLE	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.25
p.V1111M	ACH-001656	Leukemia	CCLE	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.25
p.Y1110H	SIDM00783	Colorectal Carcinoma	GDSC	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.2778
p.Y1110H	ACH-000971	Colon/Colorectal Cancer	CCLE	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.2778
p.Y1110H	HCT-116	large intestine	COSMIC	VLTPENS	DEG_SCF_FBW7_1	1102:1108	Mutation rewiring degron network	0.2778

Kaplan plot for RBM20 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RBM20

UniProt ID: Q5T481

Entrez ID: 282996

Protein name: RNA-binding protein 20 (RNA-binding motif protein 20)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RBM20 in