DegronMD

Uniprot ID: Q5T481

Source protein: RNA-binding protein 20

Source gene: RBM20

Class: DEG_SCF_FBW7_1

Location: 1102:1108

E3 ligase: FBXW7

DEGRON score: 0.9443

ASA_SCORE: 93.8429

COIL: 0.7773

CONS_SCORE: 0.3966

DSS_SCORE: 0.4513

HELIX: 0.1676

FCONS_SCORE: 0.6959

RIG_SCORE: 0.741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1113I	TCGA-A2-A1FZ	BRCA	TCGA	VLTPENS	DEG_SCF_FBW7_1	0.1944
p.M1113I	DO2770	BRCA	ICGC	VLTPENS	DEG_SCF_FBW7_1	0.1944
p.S1115Y	TCGA-AN-A046	BRCA	TCGA	VLTPENS	DEG_SCF_FBW7_1	0.5833
p.S1115Y	DO1285	BRCA	ICGC	VLTPENS	DEG_SCF_FBW7_1	0.5833
p.S1115Y	DO8898	COAD	ICGC	VLTPENS	DEG_SCF_FBW7_1	0.5833
p.S1115Y	DO8730	COAD	ICGC	VLTPENS	DEG_SCF_FBW7_1	0.5833
p.E1101G	TCGA-D1-A16N	UCEC	TCGA	VLTPENS	DEG_SCF_FBW7_1	0.3056
p.E1101G	DO43771	UCEC	ICGC	VLTPENS	DEG_SCF_FBW7_1	0.3056
p.V1111M	SIDM00607	Glioblastoma	GDSC	VLTPENS	DEG_SCF_FBW7_1	0.25
p.V1111M	SIDM00245	Small Cell Lung Carcinoma	GDSC	VLTPENS	DEG_SCF_FBW7_1	0.25
p.V1111M	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VLTPENS	DEG_SCF_FBW7_1	0.25
p.V1111M	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	VLTPENS	DEG_SCF_FBW7_1	0.25
p.V1111M	ACH-000261	Lung Cancer	CCLE	VLTPENS	DEG_SCF_FBW7_1	0.25
p.V1111M	ACH-000561	Esophageal Cancer	CCLE	VLTPENS	DEG_SCF_FBW7_1	0.25
p.V1111M	ACH-000622	Brain Cancer	CCLE	VLTPENS	DEG_SCF_FBW7_1	0.25
p.V1111M	ACH-000865	Esophageal Cancer	CCLE	VLTPENS	DEG_SCF_FBW7_1	0.25
p.V1111M	ACH-001036	Leukemia	CCLE	VLTPENS	DEG_SCF_FBW7_1	0.25
p.V1111M	ACH-001207	Non-Cancerous	CCLE	VLTPENS	DEG_SCF_FBW7_1	0.25
p.V1111M	ACH-001656	Leukemia	CCLE	VLTPENS	DEG_SCF_FBW7_1	0.25
p.Y1110H	SIDM00783	Colorectal Carcinoma	GDSC	VLTPENS	DEG_SCF_FBW7_1	0.2778
p.Y1110H	ACH-000971	Colon/Colorectal Cancer	CCLE	VLTPENS	DEG_SCF_FBW7_1	0.2778
p.Y1110H	HCT-116	large_intestine	COSMIC	VLTPENS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T481	RNA-binding protein 20	DEG_SCF_FBW7_1	1102:1108	VLTPENS	FBXW7	0.9443	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons