DegronMD - Q5T4B2(CERCAM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S552F	TCGA-13-1488	OV	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.1667
p.S552F	DO29438	OV	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.1667
p.R561C	TCGA-29-1763	OV	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation altering degron motif	0.719
p.R561C	DO28422	OV	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation altering degron motif	0.719
p.R573C	TCGA-2W-A8YY	CESC	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.0833
p.R573C	DO223732	CESC	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.0833
p.P554L	TCGA-FS-A1Z0	SKCM	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.2222
p.P554L	DO220877	MELA	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.2222
p.P554L	DO37431	SKCM	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.2222
p.G567S	TCGA-IN-A6RO	STAD	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.25
p.G567S	DO51740	STAD	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.25
p.S552Y	TCGA-XF-A9T8	BLCA	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.1667
p.S552Y	DO51927	BLCA	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.1667
p.R561H	DO233918	GACA	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation altering degron motif	0.7133
p.Q569H	DO228198	LICA	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.1944
p.T571P	ACH-000293	Endometrial/Uterine Cancer	CCLE	DSGRLIS	DEG_SCF_TRCP1_1	558:564	Mutation rewiring degron network	0.1389

Kaplan plot for CERCAM in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CERCAM

UniProt ID: Q5T4B2

Entrez ID: 51148

Protein name: Inactive glycosyltransferase 25 family member 3 (Cerebral endothelial cell adhesion molecule)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CERCAM in