DegronMD

Uniprot ID: Q5T4B2

Source protein: Inactive glycosyltransferase 25 family member 3

Source gene: CERCAM

Class: DEG_SCF_TRCP1_1

Location: 558:564

E3 ligase: BTRC

DEGRON score: 0.9731

ASA_SCORE: 76.8714

COIL: 0.6744

CONS_SCORE: 0.2693

DSS_SCORE: 0.5184

HELIX: 0.0477

FCONS_SCORE: 0.6713

RIG_SCORE: 0.7362

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S552F	TCGA-13-1488	OV	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	0.1667
p.S552F	DO29438	OV	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	0.1667
p.R561C	TCGA-29-1763	OV	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	0.719
p.R561C	DO28422	OV	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	0.719
p.R573C	TCGA-2W-A8YY	CESC	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	0.0833
p.R573C	DO223732	CESC	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	0.0833
p.P554L	TCGA-FS-A1Z0	SKCM	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	0.2222
p.P554L	DO220877	MELA	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	0.2222
p.P554L	DO37431	SKCM	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	0.2222
p.G567S	TCGA-IN-A6RO	STAD	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	0.25
p.G567S	DO51740	STAD	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	0.25
p.S552Y	TCGA-XF-A9T8	BLCA	TCGA	DSGRLIS	DEG_SCF_TRCP1_1	0.1667
p.S552Y	DO51927	BLCA	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	0.1667
p.R561H	DO233918	GACA	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	0.7133
p.Q569H	DO228198	LICA	ICGC	DSGRLIS	DEG_SCF_TRCP1_1	0.1944
p.T571P	ACH-000293	Endometrial/Uterine Cancer	CCLE	DSGRLIS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T4B2	Inactive glycosyltransferase 25 family member 3	DEG_SCF_TRCP1_1	558:564	DSGRLIS	BTRC	0.9731	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons