DegronMD - Q5T4F4(ZFYVE27)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S272F	TCGA-21-1079	LUSC	TCGA	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.1389
p.L270I	TCGA-57-1994	OV	TCGA	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.1944
p.L270I	DO30510	OV	ICGC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.1944
p.T261M	TCGA-A5-A0G2	UCEC	TCGA	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation altering degron motif	0.7423
p.T261M	TCGA-AA-3864	COAD	TCGA	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation altering degron motif	0.7423
p.T261M	SIDM01943	Colorectal Carcinoma	GDSC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation altering degron motif	0.7423
p.P266H	TCGA-EE-A29X	SKCM	TCGA	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.3056
p.P266H	DO37595	SKCM	ICGC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.3056
p.L270F	TCGA-W3-AA1V	SKCM	TCGA	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.1944
p.L270F	DO51276	SKCM	ICGC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.1944
p.F255L	DO51936	BLCA	ICGC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.25
p.V275M	DO10582	COAD	ICGC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.0556
p.A258V	DO233272	GACA	ICGC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation altering degron motif	0.6936
p.A258V	DO52402	UCEC	ICGC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation altering degron motif	0.6936
p.A263S	DO229028	LICA	ICGC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation altering degron motif	0.6477
p.P251L	DO51272	SKCM	ICGC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.1389
p.G252E	SIDM01617	Endometrial Carcinoma	GDSC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.1667
p.G252E	ACH-000994	Endometrial/Uterine Cancer	CCLE	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.1667
p.T267M	ACH-001422	Prostate Cancer	CCLE	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.2778
p.V251I	ACH-001719	Ovarian Cancer	CCLE	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.1389
p.P267L	697	haematopoietic and lymphoid tissue	COSMIC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.2778
p.C250R	HEC-1	endometrium	COSMIC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.1111
p.C257R	HEC-1	endometrium	COSMIC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation rewiring degron network	0.3056
p.A258T	CTV-1	haematopoietic and lymphoid tissue	COSMIC	MDSTPALT	DEG_SCF_FBW7_1	258:265	Mutation altering degron motif	0.7139

Kaplan plot for ZFYVE27 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFYVE27

UniProt ID: Q5T4F4

Entrez ID: 118813

Protein name: Protrudin (Spastic paraplegia 33 protein) (Zinc finger FYVE domain-containing protein 27)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ZFYVE27 in