DegronMD

Uniprot ID: Q5T4F4

Source protein: Protrudin

Source gene: ZFYVE27

Class: DEG_SCF_FBW7_1

Location: 258:265

E3 ligase: FBXW7

DEGRON score: 0.9201

ASA_SCORE: 71.5875

COIL: 0.8321

CONS_SCORE: 0.2979

DSS_SCORE: 0.8301

HELIX: 0.0818

FCONS_SCORE: 0.788

RIG_SCORE: 0.63

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T261M	TCGA-A5-A0G2	UCEC	TCGA	MDSTPALT	DEG_SCF_FBW7_1	0.7423
p.T261M	TCGA-AA-3864	COAD	TCGA	MDSTPALT	DEG_SCF_FBW7_1	0.7423
p.T261M	SIDM01943	Colorectal Carcinoma	GDSC	MDSTPALT	DEG_SCF_FBW7_1	0.7423
p.A258T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	MDSTPALT	DEG_SCF_FBW7_1	0.7139
p.A258V	DO233272	GACA	ICGC	MDSTPALT	DEG_SCF_FBW7_1	0.6936
p.A258V	DO52402	UCEC	ICGC	MDSTPALT	DEG_SCF_FBW7_1	0.6936
p.A263S	DO229028	LICA	ICGC	MDSTPALT	DEG_SCF_FBW7_1	0.6477
p.P266H	TCGA-EE-A29X	SKCM	TCGA	MDSTPALT	DEG_SCF_FBW7_1	0.3056
p.P266H	DO37595	SKCM	ICGC	MDSTPALT	DEG_SCF_FBW7_1	0.3056
p.C257R	HEC-1	endometrium	COSMIC	MDSTPALT	DEG_SCF_FBW7_1	0.3056
p.T267M	ACH-001422	Prostate Cancer	CCLE	MDSTPALT	DEG_SCF_FBW7_1	0.2778
p.P267L	697	haematopoietic_and_lymphoid_tissue	COSMIC	MDSTPALT	DEG_SCF_FBW7_1	0.2778
p.F255L	DO51936	BLCA	ICGC	MDSTPALT	DEG_SCF_FBW7_1	0.25
p.L270I	TCGA-57-1994	OV	TCGA	MDSTPALT	DEG_SCF_FBW7_1	0.1944
p.L270I	DO30510	OV	ICGC	MDSTPALT	DEG_SCF_FBW7_1	0.1944
p.L270F	TCGA-W3-AA1V	SKCM	TCGA	MDSTPALT	DEG_SCF_FBW7_1	0.1944
p.L270F	DO51276	SKCM	ICGC	MDSTPALT	DEG_SCF_FBW7_1	0.1944
p.G252E	SIDM01617	Endometrial Carcinoma	GDSC	MDSTPALT	DEG_SCF_FBW7_1	0.1667
p.G252E	ACH-000994	Endometrial/Uterine Cancer	CCLE	MDSTPALT	DEG_SCF_FBW7_1	0.1667
p.S272F	TCGA-21-1079	LUSC	TCGA	MDSTPALT	DEG_SCF_FBW7_1	0.1389
p.P251L	DO51272	SKCM	ICGC	MDSTPALT	DEG_SCF_FBW7_1	0.1389
p.V251I	ACH-001719	Ovarian Cancer	CCLE	MDSTPALT	DEG_SCF_FBW7_1	0.1389
p.C250R	HEC-1	endometrium	COSMIC	MDSTPALT	DEG_SCF_FBW7_1	0.1111
p.V275M	DO10582	COAD	ICGC	MDSTPALT	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T4F4	Protrudin	DEG_SCF_FBW7_1	258:265	MDSTPALT	FBXW7	0.9201	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons