DegronMD - Q5T5A4(CFAP276)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N121S	TCGA-C8-A12Y	BRCA	TCGA	PPTPPIT	DEG_SCF_FBW7_1	117:123	Mutation altering degron motif	0.7069
p.G132R	TCGA-FW-A3R5	SKCM	TCGA	PPTPPIT	DEG_SCF_FBW7_1	117:123	Mutation rewiring degron network	0.0833
p.P110S	DO222686	ESCA	ICGC	PPTPPIT	DEG_SCF_FBW7_1	117:123	Mutation rewiring degron network	0.1389
p.F128L	DO229029	LICA	ICGC	PPTPPIT	DEG_SCF_FBW7_1	117:123	Mutation rewiring degron network	0.1944
p.V108L	DO45117	LIRI	ICGC	PPTPPIT	DEG_SCF_FBW7_1	117:123	Mutation rewiring degron network	0.0833
p.D124N	DO36332	PRAD	ICGC	PPTPPIT	DEG_SCF_FBW7_1	117:123	Mutation rewiring degron network	0.3056
p.S120F	DO51276	SKCM	ICGC	PPTPPIT	DEG_SCF_FBW7_1	117:123	Mutation altering degron motif	0.7982
p.R117K	SIDM00837	Colorectal Carcinoma	GDSC	PPTPPIT	DEG_SCF_FBW7_1	117:123	Mutation altering degron motif	0.7237
p.P109A	SIDM00257	Neuroblastoma	GDSC	PPTPPIT	DEG_SCF_FBW7_1	117:123	Mutation rewiring degron network	0.1111
p.S109F	ACH-000991	Colon/Colorectal Cancer	CCLE	PPTPPIT	DEG_SCF_FBW7_1	117:123	Mutation rewiring degron network	0.1111
p.S129T	ACH-001807	Liposarcoma	CCLE	PPTPPIT	DEG_SCF_FBW7_1	117:123	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons