DegronMD

Uniprot ID: Q5T5A4

Source protein: Protein CFAP276

Source gene: CFAP276

Class: DEG_SCF_FBW7_1

Location: 117:123

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 83.7143

COIL: 0.9169

CONS_SCORE: 0.5099

DSS_SCORE: 0.3747

HELIX: 0.0289

FCONS_SCORE: 0.7931

RIG_SCORE: 0.7891

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S120F	DO51276	SKCM	ICGC	PPTPPIT	DEG_SCF_FBW7_1	0.7982
p.R117K	SIDM00837	Colorectal Carcinoma	GDSC	PPTPPIT	DEG_SCF_FBW7_1	0.7237
p.N121S	TCGA-C8-A12Y	BRCA	TCGA	PPTPPIT	DEG_SCF_FBW7_1	0.7069
p.D124N	DO36332	PRAD	ICGC	PPTPPIT	DEG_SCF_FBW7_1	0.3056
p.F128L	DO229029	LICA	ICGC	PPTPPIT	DEG_SCF_FBW7_1	0.1944
p.S129T	ACH-001807	Liposarcoma	CCLE	PPTPPIT	DEG_SCF_FBW7_1	0.1667
p.P110S	DO222686	ESCA	ICGC	PPTPPIT	DEG_SCF_FBW7_1	0.1389
p.P109A	SIDM00257	Neuroblastoma	GDSC	PPTPPIT	DEG_SCF_FBW7_1	0.1111
p.S109F	ACH-000991	Colon/Colorectal Cancer	CCLE	PPTPPIT	DEG_SCF_FBW7_1	0.1111
p.G132R	TCGA-FW-A3R5	SKCM	TCGA	PPTPPIT	DEG_SCF_FBW7_1	0.0833
p.V108L	DO45117	LIRI	ICGC	PPTPPIT	DEG_SCF_FBW7_1	0.0833

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5A4	Protein CFAP276	DEG_SCF_FBW7_1	117:123	PPTPPIT	FBXW7	0.9956	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons