DegronMD - Q5T6F0(DCAF12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R44K	TCGA-AD-6899	COAD	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.3056
p.R44K	DO8818	COAD	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.3056
p.R38I	TCGA-AG-A002	READ	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6991
p.R38I	TCGA-BS-A0UF	UCEC	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6991
p.R38I	DO8264	COAD	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6991
p.R38I	DO41488	UCEC	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6991
p.R38I	SIDM00193	Colorectal Carcinoma	GDSC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6991
p.R38I	ACH-000991	Colon/Colorectal Cancer	CCLE	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6991
p.R38I	SNU-81	large intestine	COSMIC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6991
p.P41L	TCGA-AO-A12D	BRCA	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6471
p.P41L	DO4707	BRCA	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6471
p.P41L	ACH-000960	Leukemia	CCLE	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6471
p.Q26R	TCGA-D1-A103	UCEC	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.Q26R	DO42312	UCEC	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833
p.R53W	TCGA-DK-A1AC	BLCA	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.R53W	DO514	BLCA	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.R53W	SIDM00545	Melanoma	GDSC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.R53W	ACH-000987	Skin Cancer	CCLE	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.R53W	Mewo	skin	COSMIC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.Y49F	TCGA-G2-A2ES	BLCA	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667
p.Y49F	DO785	BLCA	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667
p.R53P	TCGA-HD-7229	HNSC	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.R53P	DO15479	HNSC	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.L46S	TCGA-XF-A9T6	BLCA	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.25
p.L46S	DO51926	BLCA	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.25
p.K37R	DO45064	LINC	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6126
p.H31Q	DO229232	THCA	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.2222
p.K51Q	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation substituting flanking lysine	0.2222
p.K51Q	SIDM01490	Small Cell Lung Carcinoma	GDSC	KRKRLPPVK	DEG_APCC_DBOX_1	35:43	Mutation substituting flanking lysine	0.2222

Kaplan plot for DCAF12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCAF12

UniProt ID: Q5T6F0

Entrez ID: 25853

Protein name: DDB1- and CUL4-associated factor 12 (Centrosome-related protein TCC52) (Testis cancer centrosome-related protein) (WD repeat-containing protein 40A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCAF12 in