DegronMD

Uniprot ID: Q5T6F0

Source protein: DDB1- and CUL4-associated factor 12

Source gene: DCAF12

Class: DEG_APCC_DBOX_1

Location: 35:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8998

ASA_SCORE: 105.5

COIL: 0.7638

CONS_SCORE: 0.2536

DSS_SCORE: 0.3705

HELIX: 0.1476

FCONS_SCORE: 0.8378

RIG_SCORE: 0.7375

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R44K	TCGA-AD-6899	COAD	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	0.3056
p.R44K	DO8818	COAD	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	0.3056
p.R38I	TCGA-AG-A002	READ	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	0.6991
p.R38I	TCGA-BS-A0UF	UCEC	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	0.6991
p.R38I	DO8264	COAD	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	0.6991
p.R38I	DO41488	UCEC	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	0.6991
p.R38I	SIDM00193	Colorectal Carcinoma	GDSC	KRKRLPPVK	DEG_APCC_DBOX_1	0.6991
p.R38I	ACH-000991	Colon/Colorectal Cancer	CCLE	KRKRLPPVK	DEG_APCC_DBOX_1	0.6991
p.R38I	SNU-81	large_intestine	COSMIC	KRKRLPPVK	DEG_APCC_DBOX_1	0.6991
p.P41L	TCGA-AO-A12D	BRCA	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	0.6471
p.P41L	DO4707	BRCA	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	0.6471
p.P41L	ACH-000960	Leukemia	CCLE	KRKRLPPVK	DEG_APCC_DBOX_1	0.6471
p.Q26R	TCGA-D1-A103	UCEC	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	0.0833
p.Q26R	DO42312	UCEC	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	0.0833
p.R53W	TCGA-DK-A1AC	BLCA	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	0.0556
p.R53W	DO514	BLCA	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	0.0556
p.R53W	SIDM00545	Melanoma	GDSC	KRKRLPPVK	DEG_APCC_DBOX_1	0.0556
p.R53W	ACH-000987	Skin Cancer	CCLE	KRKRLPPVK	DEG_APCC_DBOX_1	0.0556
p.R53W	Mewo	skin	COSMIC	KRKRLPPVK	DEG_APCC_DBOX_1	0.0556
p.Y49F	TCGA-G2-A2ES	BLCA	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	0.1667
p.Y49F	DO785	BLCA	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	0.1667
p.R53P	TCGA-HD-7229	HNSC	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	0.0556
p.R53P	DO15479	HNSC	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	0.0556
p.L46S	TCGA-XF-A9T6	BLCA	TCGA	KRKRLPPVK	DEG_APCC_DBOX_1	0.25
p.L46S	DO51926	BLCA	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	0.25
p.K37R	DO45064	LINC	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	0.6126
p.H31Q	DO229232	THCA	ICGC	KRKRLPPVK	DEG_APCC_DBOX_1	0.2222
p.K51Q	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	KRKRLPPVK	DEG_APCC_DBOX_1	0.2222
p.K51Q	SIDM01490	Small Cell Lung Carcinoma	GDSC	KRKRLPPVK	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRKRLPPVK

Degron related mutations and impact score

Drug responses associated with DCAF12 mutations

All proteins holding degron of KRKRLPPVK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T6F0	DDB1- and CUL4-associated factor 12	DEG_APCC_DBOX_1	35:43	KRKRLPPVK	APC,CDC20,FZR1	0.8998	More...