DegronMD - Q5T7W0(ZNF618)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A330V	TCGA-2W-A8YY	CESC	TCGA	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.1944
p.S336L	TCGA-2W-A8YY	CESC	TCGA	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation altering degron motif	0.7667
p.R337H	DO223732	CESC	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation altering degron motif	0.7133
p.R337H	DO42568	UCEC	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation altering degron motif	0.7133
p.V328M	DO234303	ESAD	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.1389
p.R348H	DO49421	PACA	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.1667
p.R348H	DO232761	PBCA	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.1667
p.S352L	DO35549	PBCA	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.0556
p.S352L	DO41542	UCEC	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.0556
p.S352L	DO42713	UCEC	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.0556
p.S352L	HT-115	large intestine	COSMIC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.0556
p.R337C	DO42592	UCEC	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation altering degron motif	0.719
p.R335W	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation altering degron motif	0.8634
p.A332T	PF-382	haematopoietic and lymphoid tissue	COSMIC	LHRTPPAT	DEG_SCF_FBW7_1	335:342	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons