DegronMD

Uniprot ID: Q5T7W0

Source protein: Zinc finger protein 618

Source gene: ZNF618

Class: DEG_SCF_FBW7_1

Location: 335:342

E3 ligase: FBXW7

DEGRON score: 0.9681

ASA_SCORE: 79.2875

COIL: 0.7375

CONS_SCORE: 0.349

DSS_SCORE: 0.596

HELIX: 0.04

FCONS_SCORE: 0.9561

RIG_SCORE: 0.7125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A330V	TCGA-2W-A8YY	CESC	TCGA	LHRTPPAT	DEG_SCF_FBW7_1	0.1944
p.S336L	TCGA-2W-A8YY	CESC	TCGA	LHRTPPAT	DEG_SCF_FBW7_1	0.7667
p.R337H	DO223732	CESC	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	0.7133
p.R337H	DO42568	UCEC	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	0.7133
p.V328M	DO234303	ESAD	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	0.1389
p.R348H	DO49421	PACA	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	0.1667
p.R348H	DO232761	PBCA	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	0.1667
p.S352L	DO35549	PBCA	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	0.0556
p.S352L	DO41542	UCEC	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	0.0556
p.S352L	DO42713	UCEC	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	0.0556
p.S352L	HT-115	large_intestine	COSMIC	LHRTPPAT	DEG_SCF_FBW7_1	0.0556
p.R337C	DO42592	UCEC	ICGC	LHRTPPAT	DEG_SCF_FBW7_1	0.719
p.R335W	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LHRTPPAT	DEG_SCF_FBW7_1	0.8634
p.A332T	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LHRTPPAT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T7W0	Zinc finger protein 618	DEG_SCF_FBW7_1	335:342	LHRTPPAT	FBXW7	0.9681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons