DegronMD - Q5T7W7(TSTD2)

TSTD2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P489T	DO229028	LICA	ICGC	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.5919
p.D8E	DO229038	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	2:6	Mutation rewiring degron network	0.2778
p.P504T	DO229037	LICA	ICGC	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1389
p.L3M	DO47717	STAD	ICGC	PSSTS	DEG_SPOP_SBC_1	2:6	Mutation altering degron motif	0.711
p.R487H	SIDM00985	Burkitt's Lymphoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.2778
p.R487H	SIDM00027	Kidney Carcinoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.2778
p.R484Q	SIDM00572	Gastric Carcinoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1944
p.R484Q	ACH-000911	Gastric Cancer	CCLE	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1944
p.R484Q	NUGC-3	stomach	COSMIC	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.1944
p.L493S	SIDM00846	Cervical Carcinoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.7667
p.L493S	ACH-001086	Cervical Cancer	CCLE	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.7667
p.L493S	HeLa	cervix	COSMIC	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation altering degron motif	0.7667
p.P506T	SIDM00731	Small Cell Lung Carcinoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.0833
p.P506T	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	489:497	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc