DegronMD

Uniprot ID: Q5T7W7

Source protein: Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

Source gene: TSTD2

Class: DEG_APCC_DBOX_1

Location: 489:497

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6081

ASA_SCORE: 95.2667

COIL: 0.3514

CONS_SCORE: 0.3292

DSS_SCORE: 0.5911

HELIX: 0.6417

FCONS_SCORE: 0.9186

RIG_SCORE: 0.7152

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P489T	DO229028	LICA	ICGC	PRELLQHVR	DEG_APCC_DBOX_1	0.5919
p.P504T	DO229037	LICA	ICGC	PRELLQHVR	DEG_APCC_DBOX_1	0.1389
p.R487H	SIDM00985	Burkitt's Lymphoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	0.2778
p.R487H	SIDM00027	Kidney Carcinoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	0.2778
p.R484Q	SIDM00572	Gastric Carcinoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	0.1944
p.R484Q	ACH-000911	Gastric Cancer	CCLE	PRELLQHVR	DEG_APCC_DBOX_1	0.1944
p.R484Q	NUGC-3	stomach	COSMIC	PRELLQHVR	DEG_APCC_DBOX_1	0.1944
p.L493S	SIDM00846	Cervical Carcinoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	0.7667
p.L493S	ACH-001086	Cervical Cancer	CCLE	PRELLQHVR	DEG_APCC_DBOX_1	0.7667
p.L493S	HeLa	cervix	COSMIC	PRELLQHVR	DEG_APCC_DBOX_1	0.7667
p.P506T	SIDM00731	Small Cell Lung Carcinoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	0.0833
p.P506T	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	PRELLQHVR	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T7W7	Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2	DEG_APCC_DBOX_1	489:497	PRELLQHVR	APC,CDC20,FZR1	0.6081	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons