DegronMD - Q5TBE3(C9orf153)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S65T	TCGA-25-2404	OV	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation rewiring degron network	0.1389
p.S65T	DO32049	OV	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation rewiring degron network	0.1389
p.R73S	TCGA-34-5236	LUSC	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation altering degron motif	0.7427
p.R73S	DO26778	LUSC	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation altering degron motif	0.7427
p.G74V	TCGA-63-A5MS	LUSC	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation altering degron motif	0.6421
p.G74V	DO219161	LUSC	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation altering degron motif	0.6421
p.L76F	TCGA-D1-A17Q	UCEC	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation altering degron motif	0.6981
p.L76F	DO41903	UCEC	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation altering degron motif	0.6981
p.F66L	TCGA-HQ-A5NE	BLCA	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation rewiring degron network	0.1667
p.F66L	DO51900	BLCA	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation rewiring degron network	0.1667
p.D71N	TCGA-MF-A522	LUSC	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation rewiring degron network	0.3056
p.D71N	DO45526	LUSC	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation rewiring degron network	0.3056
p.A70S	DO228278	LICA	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation rewiring degron network	0.2778
p.Q77K	DO228948	LICA	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation altering degron motif	0.5833
p.K88N	DO45277	LIRI	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	72:80	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons