DegronMD

Uniprot ID: Q5TBE3

Source protein: Uncharacterized protein C9orf153

Source gene: C9orf153

Class: DEG_APCC_DBOX_1

Location: 72:80

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8076

ASA_SCORE: 70.9889

COIL: 0.6227

CONS_SCORE: 0.6139

DSS_SCORE: 0.4487

HELIX: 0.0386

FCONS_SCORE: 1.1087

RIG_SCORE: 0.7544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S65T	TCGA-25-2404	OV	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	0.1389
p.S65T	DO32049	OV	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	0.1389
p.R73S	TCGA-34-5236	LUSC	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	0.7427
p.R73S	DO26778	LUSC	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	0.7427
p.G74V	TCGA-63-A5MS	LUSC	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	0.6421
p.G74V	DO219161	LUSC	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	0.6421
p.L76F	TCGA-D1-A17Q	UCEC	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	0.6981
p.L76F	DO41903	UCEC	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	0.6981
p.F66L	TCGA-HQ-A5NE	BLCA	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	0.1667
p.F66L	DO51900	BLCA	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	0.1667
p.D71N	TCGA-MF-A522	LUSC	TCGA	VRGDLQPVI	DEG_APCC_DBOX_1	0.3056
p.D71N	DO45526	LUSC	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	0.3056
p.A70S	DO228278	LICA	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	0.2778
p.Q77K	DO228948	LICA	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	0.5833
p.K88N	DO45277	LIRI	ICGC	VRGDLQPVI	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TBE3	Uncharacterized protein C9orf153	DEG_APCC_DBOX_1	72:80	VRGDLQPVI	APC,CDC20,FZR1	0.8076	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons